Directorate of Postgraduate Studies

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Browsing Directorate of Postgraduate Studies by Author "Daud, Naima A."

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    Bacterial profile of amniotic fluid infection among women with premature rupture of membranes at Amana regional referral hospital: magnitude, aetiology and antimicrobial susceptibility in Tanzania
    (Kairuki University, 2024) Daud, Naima A.
    Introduction : Premature rupture of the membrane is a frequent finding in maternity wards and constitutes a major concern for fetal maternal well-being. This study determined the magnitude of amniotic fluid infection, the common bacteria isolated, and their susceptibility to the common antibiotic used among pregnant mothers with premature rupture of membranes attending Amana regional referral hospital. Methods : This study utilized a cross-sectional design involving pregnant women with premature rupture of membranes. Amniotic fluid from study participants was collected using standard methods ; amniotic fluid culture was done using Gram staining technique and sensitivity of isolated pathogens was tested using Kirby-Bauer disc diffusion method. The method for analyzing the data used was descriptive statistics. Results : This study found a magnitude of infected amniotic fluid infection among pregnant mother with premature rupture of membrane at (19.1%) corresponding to 21 out of 110 participants. E. coli followed by klebsiella were the prevalent microbial isolated with respectively rate of (42.8 %) n=9 and (33.3 %) n=7. Ciprofloxacin followed by gentamicin were the most active antibiotic in all isolated bacteria. The least active agents were ampicillin and ceftazidime. Conclusions: The magnitude of amniotic fluid infection among pregnant mothers attending Amana Referral Hospital was high among study participants. The most common isolated bacteria were E.coli and Klebsiella pneumonia. Despite the fact that Ampicillin is the first line recommended treatment or prophylaxis when amniotic fluid infection is suspected, it was the least sensitive among the isolates whereas ciprofloxacin and gentamicin were the most sensitive antibiotics among the isolates. Whenever amnionitis is suspected, amniotic fluid culture and sensitivity should be considered for rational use of appropriate antibiotics. Additionally, further studies involving larger sample size and larger geographical distribution and routine surveillance are needed to have more insight on this problem.