Anticonvulsant activity of diospyros fischeri root extracts
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Date
2007
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Publisher
African Journal of Traditional, Complementary and Alternative Medicines
Abstract
Diospyros fischeri Gurke (Ebenaceae) is used in traditional medicine for the treatment of
epilepsy. Dichloromethane, ethylacetate, and ethanol extracts of the roots, at doses between 100 and
1600 mg/kg BW, inhibited convulsions induced by the γ‐aminobutyric acid type A (GABAA) receptor
antagonist, pentylenetetrazole (PTZ), in a dose dependent manner. The extracts also exhibited low
toxicity against brine shrimps giving LC50 values between 45 .4 and 95.4 μg/ml. These results provide
evidence for the potential of D. fischeri extracts to treat absence seizures, especially given their
seemingly innocuous nature.
Keywords: Diospyros fischeri; Pentylenetetrazole; Anticonvulsant activity; Brine shrimp toxicity
Description
Keywords
Diospyros fischeri, Pentylenetetrazole, Anticonvulsant activity
Citation
Moshi, M.J., Mbwambo, Z.H., Nondo, R.S., Masimba, P.J., Kapingu, M.C. and Magelewanya, E.S., 2007. Anticonvulsant activity of Diospyros fischeri root extracts. African Journal of Traditional, Complementary and Alternative Medicines, 4(2), pp.226-230.