Anticonvulsant activity of diospyros fischeri root extracts

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dc.contributor.authorMoshi, Mainen J.
dc.date.accessioned2023-08-11T12:31:40Z
dc.date.available2023-08-11T12:31:40Z
dc.date.issued2007
dc.description.abstractDiospyros fischeri Gurke (Ebenaceae) is used in traditional medicine for the treatment of epilepsy. Dichloromethane, ethylacetate, and ethanol extracts of the roots, at doses between 100 and 1600 mg/kg BW, inhibited convulsions induced by the γ‐aminobutyric acid type A (GABAA) receptor antagonist, pentylenetetrazole (PTZ), in a dose dependent manner. The extracts also exhibited low toxicity against brine shrimps giving LC50 values between 45 .4 and 95.4 μg/ml. These results provide evidence for the potential of D. fischeri extracts to treat absence seizures, especially given their seemingly innocuous nature. Keywords: Diospyros fischeri; Pentylenetetrazole; Anticonvulsant activity; Brine shrimp toxicityen_US
dc.identifier.citationMoshi, M.J., Mbwambo, Z.H., Nondo, R.S., Masimba, P.J., Kapingu, M.C. and Magelewanya, E.S., 2007. Anticonvulsant activity of Diospyros fischeri root extracts. African Journal of Traditional, Complementary and Alternative Medicines, 4(2), pp.226-230.en_US
dc.identifier.otherDOI: 10.4314/ajtcam.v4i2.31212
dc.identifier.urihttp://hdl.handle.net/123456789/1121
dc.language.isoenen_US
dc.publisherAfrican Journal of Traditional, Complementary and Alternative Medicinesen_US
dc.subjectDiospyros fischerien_US
dc.subjectPentylenetetrazoleen_US
dc.subjectAnticonvulsant activityen_US
dc.titleAnticonvulsant activity of diospyros fischeri root extractsen_US
dc.typeArticleen_US

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