Host erythrocyte polymorphisms and exposure to Plasmodium falciparum in Papua New Guinea

Mgone, Charles S.

Host erythrocyte polymorphisms and exposure to Plasmodium falciparum in Papua New Guinea

dc.contributor.author	Mgone, Charles S.
dc.date.accessioned	2020-02-14T12:42:14Z
dc.date.available	2020-02-14T12:42:14Z
dc.date.issued	2008
dc.description.abstract	Background The protection afforded by human erythrocyte polymorphisms against the malaria parasite, Plasmodium falciparum, has been proposed to be due to reduced ability of the parasite to invade or develop in erythrocytes. If this were the case, variable levels of parasitaemia and rates of seroconversion to infected-erythrocyte variant surface antigens (VSA) should be seen in different host genotypes. Methods To test this hypothesis, P. falciparum parasitaemia and anti-VSA antibody levels were measured in a cohort of 555 asymptomatic children from an area of intense malaria transmission in Papua New Guinea. Linear mixed models were used to investigate the effect of α+-thalassaemia, complement receptor-1 and south-east Asian ovalocytosis, as well as glucose-6-phosphate dehydrogenase deficiency and ABO blood group on parasitaemia and age-specific seroconversion to VSA. Results No host polymorphism showed a significant association with both parasite prevalence/density and age-specific seroconversion to VSA. Conclusion Host erythrocyte polymorphisms commonly found in Papua New Guinea do not effect exposure to blood stage P. falciparum infection. This contrasts with data for sickle cell trait and highlights that the above-mentioned polymorphisms may confer protection against malaria via distinct mechanisms.	en_US
dc.identifier.citation	Fowkes, F.J., Michon, P., Pilling, L., Ripley, R.M., Tavul, L., Imrie, H.J., Woods, C.M., Mgone, C.S., Luty, A.J. and Day, K.P., 2008. Host erythrocyte polymorphisms and exposure to Plasmodium falciparum in Papua New Guinea. Malaria journal, 7(1), p.1.	en_US
dc.identifier.other	doi:10.1186/1475-2875-7-1
dc.identifier.uri	http://hdl.handle.net/123456789/226
dc.language.iso	en	en_US
dc.publisher	Malaria journal	en_US
dc.subject	Host erythrocyte polymorphisms	en_US
dc.subject	Plasmodium falciparum	en_US
dc.subject	Papua New Guinea	en_US
dc.title	Host erythrocyte polymorphisms and exposure to Plasmodium falciparum in Papua New Guinea	en_US
dc.type	Article	en_US