Nitric oxide in Tanzanian children with malaria: inverse relationship between malaria severity and nitric oxide production/nitric oxide synthase type 2 expression

Mwaikambo, Esther D.

Nitric oxide in Tanzanian children with malaria: inverse relationship between malaria severity and nitric oxide production/nitric oxide synthase type 2 expression

dc.contributor.author	Mwaikambo, Esther D.
dc.date.accessioned	2020-07-20T12:31:14Z
dc.date.available	2020-07-20T12:31:14Z
dc.date.issued	1996
dc.description.abstract	Summary Nitric oxide (NO)-related activity has been shown to be protective against Plasmodium faki- parum in vitro. It has been hypothesized, however, that excess NO production contributes to the pathogenesis of cerebral malaria. The purpose of this study was to compare markers of NO production [urinary and plasma nitrate + nitrite (NO~)], leukocyte-inducible nitric oxide syn- thase type 2 (NOS2), and plasma TNF-c~ and IL-10 levels with disease severity in 191 Tanza- nian children with and without malaria. Urine NO• excretion and plasma NOx levels (cor- rected for renal impairment) were inversely related to disease severity, with levels highest in subclinical infection and lowest in fatal cerebral malaria. Results could not be explained by dif- ferences in dietary nitrate ingestion among the groups. Plasma levels of IL-10, a cytokine known to suppress NO synthesis, increased with disease severity. Leukocyte NOS2 antigen was detectable in all control children tested and in all those with subclinical infection, but was undetectable in all but one subject with cerebral malaria. This suppression of NO synthesis in cerebral malaria may contribute to pathogenesis. In contrast, high fasting NO x levels and leu- kocyte NOS2 in healthy controls and asymptomatic infection suggest that increased NO syn-thesis might protect against clinical disease. NO appears to have a protective rather than patho-logical role in African children with malaria.	en_US
dc.identifier.citation	Anstey, N.M., Weinberg, J.B., Hassanali, M.Y., Mwaikambo, E.D., Manyenga, D., Misukonis, M.A., Arnelle, D.R., Hollis, D., McDonald, M.I. and Granger, D.L., 1996. Nitric oxide in Tanzanian children with malaria: inverse relationship between malaria severity and nitric oxide production/nitric oxide synthase type 2 expression. The Journal of experimental medicine, 184(2), pp.557-567.	en_US
dc.identifier.issn	https://doi.org/10.1084/jem.184.2.557
dc.identifier.uri	http://hdl.handle.net/123456789/546
dc.language.iso	en	en_US
dc.publisher	The Journal of experimental medicine	en_US
dc.subject	Nitric oxide	en_US
dc.subject	Malaria	en_US
dc.subject	Tanzania	en_US
dc.title	Nitric oxide in Tanzanian children with malaria: inverse relationship between malaria severity and nitric oxide production/nitric oxide synthase type 2 expression	en_US
dc.type	Article	en_US