Low plasma arginine concentrations in children with cerebral malaria and decreased nitric oxide production

Simple item page
dc.contributor.authorMwaikambo, Esther D.
dc.date.accessioned2020-02-17T12:09:57Z
dc.date.available2020-02-17T12:09:57Z
dc.date.issued2003
dc.description.abstractNitric oxide (NO) production and mononuclear cell NO synthase 2 (NOS2) expression are high in healthy Tanzanian children but low in those with cerebral malaria. Factors that downregulate NOS2 also diminish factors involved in cellular uptake and biosynthesis of L-arginine, the substrate for NO synthesis. We therefore postulated that L-arginine concentrations would be low in individuals with cerebral malaria. We measured concentrations of L-arginine in cryopreserved plasma samples from Tanzanian children with and without malaria. L-arginine concentrations were low in individuals with cerebral malaria (mean 46 μmol/L, SD 14), intermediate in those with uncomplicated malaria (70 μmol/L, 20), and within the normal range in healthy controls (122 μmol/L, 22; p<0·0001). Analysis by logistic regression showed that hypoargininaemia was significantly associated with cerebral malaria case-fatality. Hypoargininaemia may contribute to limited NO production in children with cerebral malaria and to severe disease.en_US
dc.identifier.citationLopansri, B.K., Anstey, N.M., Weinberg, J.B., Stoddard, G.J., Hobbs, M.R., Levesque, M.C., Mwaikambo, E.D. and Granger, D.L., 2003. Low plasma arginine concentrations in children with cerebral malaria and decreased nitric oxide production. The Lancet, 361(9358), pp.676-678.en_US
dc.identifier.otherhttp://doi.org/10.1016/S0140 - 6736(03) 12564 - 0
dc.identifier.urihttp://hdl.handle.net/123456789/237
dc.language.isoenen_US
dc.publisherThe Lanceten_US
dc.subjectLow plasma arginineen_US
dc.subjectNitric oxide productionen_US
dc.subjectCerebral malariaen_US
dc.subjectChildrenen_US
dc.titleLow plasma arginine concentrations in children with cerebral malaria and decreased nitric oxide productionen_US
dc.typeArticleen_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Low plasma arginine concentrations in children with cerebral malaria and decreased nitric oxide productio1.pdf
Size:
16.17 KB
Format:
Adobe Portable Document Format
Description:
Download

Collections

Journals

Total Collections: 1