The relation of oxidative DNA damage to hypertension and other cardiovascular risk factors in Tanzania.

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dc.contributor.authorMashalla, Yohana J.
dc.date.accessioned2022-04-06T06:39:58Z
dc.date.available2022-04-06T06:39:58Z
dc.date.issued2001-03
dc.description.abstractObjectives: To clarify the mechanism of involvement of oxidative stress in hypertensives, we investigated the relationship between the marker of oxidative DNA damage, urinary 8-hydroxy2′-deoxyguanosine (8-OHdG), and cardiovascular risk factors, such as hypertension and serum glycosylated hemoglobin (HbA1c), among Tanzanians aged 46-58 years who were not on antihypertensive medication. Design and methods: Sixty subjects (males/females, 28/32) were selected randomly from the subjects who completed a 24h urine collection in our epidemiological study at Dar es Salaam, Tanzania in 1998. The subjects were divided into two groups, hypertensive subjects (systolic blood pressure (SBP) ≥ 140 mmHg and/or diastolic blood pressure (DBP) ≥90 mmHg) and normotensive subjects (SBP <140 mmHg and DBP <90 mmHg) or hyperglycemic subjects (HbA1c ≥ 6.0%) and normoglycemic subjects (HbA1c< 6.0%). Biological markers from urine and blood were analyzed centrally in the WHO Collaborating Center. Results: The mean levels of HbA1c and 8-OHdG were significantly higher in the hypertensive subjects than in the normotensive subjects (P < 0.05). Urinary 8-OHdG was significantly higher in hyperglycemic subjects than in normoglycemic subjects. HbA1c was positively correlated with the 24-h urinary 8-OHdG excretions (r = 0.698, P < 0.0001). Conclusions These ®ndings suggest oxidative DNA damage is increased in hypertensive subjects, and there is a positive correlation between the level of blood glucose estimated as HbA1c and oxidative DNA damage.Hyperglycemia related to insulin resistance in hypertension in Tanzania is associated with increased urinary 8-OHdG. J Hypertens 19:529±533 & 2001 Lippincott Williams & Wilkins.en_US
dc.identifier.citationNegishi, H., Ikeda, K., Kuga, S., Noguchi, T., Kanda, T., Njelekela, M., Liu, L., Miki, T., Nara, Y., Sato, T. and Mashalla, Y., 2001. The relation of oxidative DNA damage to hypertension and other cardiovascular risk factors in Tanzania. Journal of hypertension, 19(3), pp.529-533.en_US
dc.identifier.otherDOI:10.1097/00004872-200103001-00002
dc.identifier.urihttp://hdl.handle.net/123456789/959
dc.language.isoenen_US
dc.publisherJournal of hypertensionen_US
dc.subject8-hydroxy-2'-deoxyguanosineen_US
dc.subjectHypertensionen_US
dc.subjectGlycosylated hemoglobinen_US
dc.titleThe relation of oxidative DNA damage to hypertension and other cardiovascular risk factors in Tanzania.en_US
dc.typeArticleen_US

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