Combination of probenecid-sulphadoxine-pyrimethamine for intermittent preventive treatment in pregnancy

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dc.contributor.authorMutabingwa, Theonest K.
dc.date.accessioned2020-03-09T09:25:46Z
dc.date.available2020-03-09T09:25:46Z
dc.date.issued2012
dc.description.abstractThe antifolate sulphadoxine-pyrimethamine (SP) has been used in the intermittent prevention of malaria in pregnancy (IPTp). SP is an ideal choice for IPTp, however, as resistance of Plasmodium falciparum to SP increases, data are accumulating that SP may no longer provide benefit in areas of high-level resistance. Probenecid was initially used as an adjunctive therapy to increase the blood concentration of penicillin; it has since been used to augment concentrations of other drugs, including antifolates. The addition of probenecid has been shown to increase the treatment efficacy of SP against malaria, suggesting that the combination of probenecid plus SP may prolong the useful lifespan of SP as an effective agent for IPTp. Here, the literature on the pharmacokinetics, adverse reactions, interactions and available data on the use of these drugs in pregnancy is reviewed, and the possible utility of an SP-probenecid combination is discussed. This article concludes by calling for further research into this potentially useful combination.en_US
dc.identifier.citationGutman, J., Kachur, S.P., Slutsker, L., Nzila, A. and Mutabingwa, T., 2012. Combination of probenecid-sulphadoxine-pyrimethamine for intermittent preventive treatment in pregnancy. Malaria journal, 11(1), p.39.en_US
dc.identifier.otherhttps://doi.org/10.1186/1475-2875-11-39
dc.identifier.urihttp://hdl.handle.net/123456789/309
dc.language.isoenen_US
dc.publisherMalaria journalen_US
dc.subjectMalariaen_US
dc.subjectSulphadoxine-pyrimethamineen_US
dc.subjectPregnancyen_US
dc.titleCombination of probenecid-sulphadoxine-pyrimethamine for intermittent preventive treatment in pregnancyen_US
dc.typeArticleen_US

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