Hyperparasitaemia during clinical malaria episodes in infants aged 0–24 months and its association with in utero exposure to Plasmodium falciparum

Sylvester, Boniphace

Hyperparasitaemia during clinical malaria episodes in infants aged 0–24 months and its association with in utero exposure to Plasmodium falciparum

dc.contributor.author	Sylvester, Boniphace
dc.date.accessioned	2020-03-09T09:28:14Z
dc.date.available	2020-03-09T09:28:14Z
dc.date.issued	2018
dc.description.abstract	Existing information has shown that infants who are prenatally exposed to P. falciparum are susceptible to subsequent malaria infections. However, the effect of prenatal exposure to P. falciparum on parasite density during clinical malaria episodes has not been fully elucidated. This study is a component of a prospective cohort study for which initial results have been published. This component was designed to determine the effect of prenatal exposure to P. falciparum on parasite density during clinical malaria episodes in the first 24 months of life. A total of 215 infants were involved and monitored for clinical malaria episodes defined by fever (≥ 37 °C) and parasitaemia. The geometric mean parasite counts between exposed and unexposed infants were compared using independent samples t test. The effect of in utero exposure to P. falciparum on parasite density was assessed using binary logistic regression. Results The geometric mean parasite count per µl of blood during clinical malaria episodes in exposed infants was 24,889 (95% CI 18,286–31,490) while in unexposed infants it was 14,035 (95% CI 12,111–15,960), P < 0.05. Prenatal exposure to P. falciparum was associated with hyperparasitaemia during clinical malaria episodes (OR 7.04, 95% CI 2.31–21.74), while other factors were not significantly associated (P > 0.05).	en_US
dc.identifier.citation	Sylvester, B., Gasarasi, D.B., Aboud, S., Tarimo, D., Massawe, S., Mpembeni, R. and Swedberg, G., 2018. Hyperparasitaemia during clinical malaria episodes in infants aged 0–24 months and its association with in utero exposure to Plasmodium falciparum. BMC research notes, 11(1), pp.1-5.	en_US
dc.identifier.other	https://doi.org/10.1186/s13104-018-3339-0
dc.identifier.uri	http://hdl.handle.net/123456789/311
dc.language.iso	en	en_US
dc.publisher	BMC research notes	en_US
dc.subject	Parasite density	en_US
dc.subject	P. falciparum	en_US
dc.subject	Hyperparasitaemia	en_US
dc.title	Hyperparasitaemia during clinical malaria episodes in infants aged 0–24 months and its association with in utero exposure to Plasmodium falciparum	en_US
dc.type	Article	en_US