Plasma Interleukin-12 in Malaria-Tolerant Papua New Guineans:Inverse Correlation with Plasmodium falciparum Parasitemia and Peripheral Blood Mononuclear Cell Nitric Oxide Synthase Activity

Mgone, Charles S.

Plasma Interleukin-12 in Malaria-Tolerant Papua New Guineans:Inverse Correlation with Plasmodium falciparum Parasitemia and Peripheral Blood Mononuclear Cell Nitric Oxide Synthase Activity

dc.contributor.author	Mgone, Charles S.
dc.date.accessioned	2020-02-17T07:04:52Z
dc.date.available	2020-02-17T07:04:52Z
dc.date.issued	2003
dc.description.abstract	Interleukin-12 (IL-12) has been inversely associated with disease severity in human and murine malaria, and a polymorphism in the IL-12 p40 subunit gene (IL12B) has been associated with susceptibility to human cerebral malaria and reduced nitric oxide (NO) production. To better define the relationships between IL-12, NO, malaria parasitemia, and IL12B polymorphisms during malarial tolerance, plasma IL-12 levels and peripheral blood mononuclear cell NO synthase (NOS) activity were measured in asymptomatic Papua New Guineans exposed to intense malaria transmission. The IL-12 level was strongly inversely correlated with the density of Plasmodium falciparum parasitemia (ρ = −0.45; P < 0.001) and was predicted to decrease by 19% (95% confidence interval [CI], 10 to 27%) for each twofold increase in P. falciparum parasitemia. This is consistent with a suppressive effect of parasitemia on IL-12 production, an effect previously shown in vitro and in rodent models of disease. The IL-12 level was inversely correlated with NOS activity (r = −0.22; P = 0.007), with each twofold increase in NOS activity being predictive of a 25% (95% CI, 7 to 38%) decrease in plasma IL-12 levels. This probably reflects additional down-regulation of IL-12 by the high basal NO production and monocyte NOS expression found in the malaria-tolerant state. Neither the IL-12 level nor NOS activity was associated with either of two IL12B polymorphisms, reflecting the diversity of genetic control over immune responses in different populations.	en_US
dc.identifier.citation	Boutlis, C.S., Lagog, M., Chaisavaneeyakorn, S., Misukonis, M.A., Bockarie, M.J., Mgone, C.S., Wang, Z., Morahan, G., Weinberg, J.B., Udhayakumar, V. and Anstey, N.M., 2003. Plasma interleukin-12 in malaria-tolerant papua new guineans: inverse correlation with Plasmodium falciparum parasitemia and peripheral blood mononuclear cell nitric oxide synthase activity. Infection and immunity, 71(11), pp.6354-6357.	en_US
dc.identifier.other	DOI: 10.1128/IAI.71.11.6354-6357.2003
dc.identifier.uri	http://hdl.handle.net/123456789/228
dc.language.iso	en	en_US
dc.publisher	Infection and immunity	en_US
dc.subject	Plasma Interleukin-12	en_US
dc.subject	Malaria-Tolerant	en_US
dc.subject	Plasmodium falciparum Parasitemia	en_US
dc.subject	Peripheral Blood Mononuclear Cell Nitric Oxide Synthase	en_US
dc.subject	Papua New Guineans	en_US
dc.title	Plasma Interleukin-12 in Malaria-Tolerant Papua New Guineans:Inverse Correlation with Plasmodium falciparum Parasitemia and Peripheral Blood Mononuclear Cell Nitric Oxide Synthase Activity	en_US
dc.title.alternative		en_US
dc.type	Article	en_US