Determination of appropriate clomipramine dosage among depressed African outpatients in Dar es Salaam, Tanzania

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dc.contributor.authorKilonzo, Gad P.
dc.date.accessioned2020-07-08T12:37:51Z
dc.date.available2020-07-08T12:37:51Z
dc.date.issued1994
dc.description.abstractIn an open clomipramine dose finding study, 33 deĀ­pressed indigenous African outpatients were randomly assigned to two regimens of treatment with 125 mg and 75 mg oral medications daily. At the end of eight weeks of treatment, 16 patients (48,5 pc) were on the 75 mg regime, and 17 (54,8 pc) were on 125 mg. 178 Analysis of depression scores cm the Beck-Rafaelsen scale indicated improvements of depression in both regimes of equal magnitude. Analysis of variance showed no statistically significant difference on dose response between the two regimes. The higher doses, however, were associated with more drowsiness and tremulousness. It is suggested that Black African patients respond to tricyclic antidepressants in much lower doses than those recommended in Western textbooks. It is also apparent that side effects of tricyclic antidepressants, which have been implicated in non-compliance to medication, could be avoided without compromising treatment outcomeen_US
dc.identifier.citationKilonzo, G.P., Kaaya, S.F., Rweikiza, J.K., Kassam, M. and Moshi, G., 1994. Determination of appropriate clomipramine dosage among depressed African outpatients in Dar es Salaam, Tanzania.en_US
dc.identifier.urihttps://opendocs.ids.ac.uk/opendocs/handle/20.500.12413/7050
dc.identifier.urihttp://hdl.handle.net/123456789/461
dc.language.isoenen_US
dc.publisherThe Central African Journal of Medicineen_US
dc.subjectClomipramine dosageen_US
dc.subjectDepressed African outpatientsen_US
dc.subjectDar es Salaam, Tanzaniaen_US
dc.titleDetermination of appropriate clomipramine dosage among depressed African outpatients in Dar es Salaam, Tanzaniaen_US
dc.typeArticleen_US

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