Red cell morphology and malaria anaemia in children with Southeast- Asian ovalocytosis band 3 in Papua New Guinea

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dc.contributor.authorMgone, Charles S.
dc.date.accessioned2020-03-19T09:10:51Z
dc.date.available2020-03-19T09:10:51Z
dc.date.issued1998
dc.description.abstractSoutheast-Asian ovalocytosis (SAO) was diagnosed in children from Madang, Papua New Guinea, by detection of the SAO band 3 gene variant using the polymerase chain reaction. SAO band 3 was present in 16/241 (6.6%) children living in the community and 32/389 (8.2%) children with acute Plasmodium falciparum malaria (P=0.42). SAO band 3 was detected in 8.2% (23/281) of alpha+-thalassaemia homozygotes, 9.4% (20/214) of heterozygotes and 2.4% (2/85) of children with a normal alpha-globin genotype (P=0.12). The most consistent feature of SAO band 3 on microscopy of thin blood films was red cells with two or more linear or irregularly-shaped pale regions. In children living in the community, these were present in 15 with SAO band 3 (sensitivity 93.8%) and only two normals (specificity 99.1%). The presence of > or = 20% ovalocytosis was a poorer indicator of SAO band 3 (sensitivity 68.8% and specificity 100%). Haematological data were similar in SAO band 3 and normal children. However, in children with acute malaria, haemoglobin levels and red cell counts were significantly lower in SAO band 3 than normal children. The degree of ovalocytosis was lower in children with SAO band 3 during acute malaria, suggesting that a selective loss of ovalocytes may contribute to malaria anaemia in Southeast-Asian ovalocytosis.en_US
dc.identifier.citationO'Donnell, A., Allen, S.J., Mgone, C.S., Martinson, J.J., Clegg, J.B. and Weatherall, D.J., 1998. Red cell morphology and malaria anaemia in children with Southeast-Asian ovalocytosis band 3 in Papua New Guinea. British journal of haematology, 101(3), pp.407-412.en_US
dc.identifier.otherDOI: 10.1046/j.1365-2141.1998.00742.x
dc.identifier.urihttp://hdl.handle.net/123456789/372
dc.language.isoenen_US
dc.publisherBritish journal of haematologyen_US
dc.subjectRed cell morphologyen_US
dc.subjectMalariaen_US
dc.subjectAnaemiaen_US
dc.titleRed cell morphology and malaria anaemia in children with Southeast- Asian ovalocytosis band 3 in Papua New Guineaen_US
dc.typeArticleen_US

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