Antimicrobial and brine shrimp toxicity of some plants used in traditional medicine in Bukoba District, north-western Tanzania

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dc.contributor.authorMoshi, Mainen J.
dc.date.accessioned2023-08-11T12:29:13Z
dc.date.available2023-08-11T12:29:13Z
dc.date.issued2009-01
dc.description.abstractHerbal medicines constitute a potentially important resource for new and safe drugs for the management of microbial infections and other diseases. In this study, dichloromethane, ethylacetate and ethanol extracts of Canarium schweinfurthii Engl., Dissotis brazzae Cong., Iboza urticifolia (Bak) E.A.Bruce, Isoglosa lacteal Lindau, Strombosia Scheffleri Engl., and Whitfieldia elongate T. Anders were tested for antimicrobial activity and brine shrimp toxicity. The objective was to validate claims that they are used to treat bacterial infections, diarrhoea and heal wounds among the Haya tribe of north-western Tanzania. At least one extract of each plant showed antibacterial activity. Dichloromethane extracts were the most active while ethanol extracts were the least active. Extracts of Whitfieldia elongate and Isoglossa lacteal were the most and least active with MICs in the range 0.08-0.62 mg/ml and 15.6-62.5 mg/ml, respectively. The dichloromethane extract of Whitfieldia elongate exhibited strong antifungal activity against Cryptococcus neoformans. Against brine shrimp larvae, the extracts from the six plants exhibited a low to very low toxicity with LC50 values ranging from 15.35-374.0µg/ml. However, ethanol extracts of Dissotis brazzae and Strombosia scheffleri had LC50 values of >1000µg/ml. The seemingly innocuous nature and relatively good antibacterial activity against skin infections and gastrointestinal pathogenic bacteria support the traditional uses of the plants and deserve more detailed studies.en_US
dc.identifier.citationMoshi, M.J., Innocent, E., Masimba, P.J., Otieno, D.F., Weisheit, A., Mbabazi, P., Lynes, M., Meachem, K., Hamilton, A. and Urassa, I., 2009. Antimicrobial and brine shrimp toxicity of some plants used in traditional medicine in Bukoba District, north-western Tanzania. Tanzania Journal of Health Research, 11(1).en_US
dc.identifier.otherDOI: 10.4314/thrb.v11i1.43247
dc.identifier.urihttp://hdl.handle.net/123456789/1115
dc.language.isoenen_US
dc.publisherTanzania Journal of Health Researchen_US
dc.subjectAntimicrobialsen_US
dc.subjectTanzaniaen_US
dc.subjectTraditional medicinesen_US
dc.titleAntimicrobial and brine shrimp toxicity of some plants used in traditional medicine in Bukoba District, north-western Tanzaniaen_US
dc.typeArticleen_US

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