Brine shrimp lethality of a glutarimide alkaloid from Croton sylvaticus Hochst
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Date
2005-04
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
East and Central African Journal of Pharmaceutical Sciences
Abstract
Cytotoxic properties of pure compounds from the leaves of roto on sylvaticus
(Euphorbiaceae) against brine shrimp (Artemia salina) larvae were investigated. A
glutarimide alkaloid, julocrotine (1) showed'very high cytotoxic activity with a LCs0
(95 % CI) value of 0.074 (0.052-0.105) pglml when tested in vitro while lupeol (2)
and penduliflaworisin (3) were inactive in brine shrimp lethality test. The structures
of the isolated compounds were determined by modern spectroscopic methods.
Description
Keywords
Croton sylvaticus, Euphorbiaceae, Julocrotine
Citation
Kapingu, M.C., Mbwambo, Z.H., Moshi, M.J. and Magadula, J.J., 2005. Brine shrimp lethality of a glutarimide alkaloid from Croton sylvaticus Hochst. East and Central African Journal of Pharmaceutical Sciences, 8(1), pp.3-5.