Comparative bioavailability of oral Sugar-Coated and plain formulation of chloroquine phosphate marketed in Tanzania

Moshi, Mainen J.; Massele, Amos Y.

Comparative bioavailability of oral Sugar-Coated and plain formulation of chloroquine phosphate marketed in Tanzania

dc.contributor.author	Moshi, Mainen J.
dc.contributor.author	Massele, Amos Y.
dc.date.accessioned	2023-08-11T06:04:46Z
dc.date.available	2023-08-11T06:04:46Z
dc.date.issued	2002-01
dc.description.abstract	The bioavailability of chloroquine from a single oral dose (10 mg/kg body weight) of a sugar-coated (DawaquinR) and a plain formulation (ShellyquineR) of chloroquine phosphate were compared in two groups of 10 volunteers each, following an overnight fast. Whole blood chloroquine concentrations were measured using high-performance liquid chromatography (HPLC) and bioavailability was determined by measuring area under the blood chloroquine concentration curve (AUC ng mL−1 h) and the peak blood chloroquine concentration (Cpmax ng/mL). The AUC and Cpmax for Shellyquine were 4396.3 ± 833 ng mL−1 h and 162 ± 14 ng/mL, respectively. The AUC and Cpmax for Dawaquin were 2060 ± 339 ng mL−1 h and 56.6 ± 5.2 ng/mL, respectively. Shellyquine was significantly more bioavailable than Dawaquin (P<0.001). Although the Cpmax for Dawaquin was higher than the required therapeutic level for sensitive Plasmodium falciparum of 30 ng/mL, its blood levels may not guarantee a rapid clearance of parasites. The differences between the two formulations point to a problem in the quality of pharmaceuticals marketed in this country, whose extent need to be ascertained further. Failure of chloroquine phosphate in this country has already been declared by the Ministry of Health, and the potential contribution of poorly formulated products remains a subject of debate.	en_US
dc.identifier.citation	Rimoy, G.H., Moshi, M.J. and Massele, A.Y., 2002. Comparative bioavailability of oral sugar-coated and plain formulation of chloroquine phosphate marketed in Tanzania. Tropical Doctor, 32(1), pp.15-17.	en_US
dc.identifier.other	https://doi.org/10.1177/004947550203200108
dc.identifier.uri	http://hdl.handle.net/123456789/1103
dc.language.iso	en	en_US
dc.publisher	Tropical Doctor	en_US
dc.subject	Chloroquine Phosphate	en_US
dc.subject	Tanzania	en_US
dc.subject	Bioavailability of Oral Sugar-Coated	en_US
dc.title	Comparative bioavailability of oral Sugar-Coated and plain formulation of chloroquine phosphate marketed in Tanzania	en_US
dc.type	Article	en_US