Decreased susceptibility to Plasmodium falciparum infection in pregnant women with iron deficiency
| dc.contributor.author | Mutabingwa, Theonest K. | |
| dc.date.accessioned | 2020-10-08T06:35:15Z | |
| dc.date.available | 2020-10-08T06:35:15Z | |
| dc.date.issued | 2008 | |
| dc.description.abstract | Abstract Iron plus folate supplementation increases mortality and morbidity among children in areas of malaria endemicity in Africa, but the effects of supplementation on pregnant women in malaria-endemic areas remain unclear. In northeastern Tanzania, where malaria and iron deficiency are common, we found that placental malaria was less prevalent (8.5% vs. 47.3% of women; P < .0001) and less severe (median parasite density, 4.2% vs. 6.3% of placental red blood cells; P = .04) among women with iron deficiency than among women with sufficient iron stores, especially during the first pregnancy. Multivariate analysis revealed that iron deficiency (P < .0001) and multigravidity (P = .002) significantly decreased the risk of placental malaria. Interventional trials of iron and folate supplementation during pregnancy in malaria-endemic regions in Africa are urgently needed to ascertain the benefits and risks of this intervention. | en_US |
| dc.identifier.citation | Kabyemela, E.R., Fried, M., Kurtis, J.D., Mutabingwa, T.K. and Duffy, P.E., 2008. Decreased susceptibility to Plasmodium falciparum infection in pregnant women with iron deficiency. The Journal of infectious diseases, 198(2), pp.163-166. | en_US |
| dc.identifier.other | https://doi.org/10.1086/589512 | |
| dc.identifier.uri | http://hdl.handle.net/123456789/617 | |
| dc.language.iso | en | en_US |
| dc.publisher | The Journal of infectious diseases | en_US |
| dc.subject | Africa | en_US |
| dc.subject | Malaria | en_US |
| dc.subject | Iron deficiency | en_US |
| dc.title | Decreased susceptibility to Plasmodium falciparum infection in pregnant women with iron deficiency | en_US |
| dc.type | Article | en_US |