Antibacterial and cytotoxic triterpenoids from Lantana viburnoides ssp. viburnoides var. kisi

Moshi, Mainen J.

Antibacterial and cytotoxic triterpenoids from Lantana viburnoides ssp. viburnoides var. kisi

dc.contributor.author	Moshi, Mainen J.
dc.date.accessioned	2023-08-11T12:33:35Z
dc.date.available	2023-08-11T12:33:35Z
dc.date.issued	2011-12-07
dc.description.abstract	Lantana viburnoides ssp. var. is used in traditional medicine as a mosquito repellent and sometimes chewed for treatment of gastrointestinal problems. Gastrointestinal problems are varied and may include microbial infections, parasitic infestation; inflammatory bowel disease, malignancies, peptic ulcers, or simply colic pains. This work seeks to establish proof of the concept on safety and efficacy for treatment of bacterial infections. METHODS Root and stem bark ethanol extracts, extract fractions and two isolated compounds were tested for antibacterial activity against five standard Gram positive and two Gram negative bacteria using the broth micro-dilution method. The extracts and isolated compounds were also tested for cytotoxic activity against brine shrimp larvae ( ). RESULTS The stem and root bark ethanol extracts exhibited strong antibacterial activity against (195.3 μg/ml) and (390.6 μg/ml). Camaric acid (1), isolated from the dichloromethane fraction of root bark extract, exhibited antimicrobial activity against (MIC = 19.5 μg/ml) (MIC = 19.5 μg/ml) (MIC = 9.76 μg/ml), (MIC = 4.88 μg/ml), and (MIC = 19.5 μg/ml), and was toxic to the shrimps (LC50 = 4.1 μg/ml). Betulinic acid (2) also from the same fraction exhibited poor anti-bacterial activity against all bacteria tested but showed high cytotoxic activity against brine shrimp larvae (LC50 = 2.4 μg/ml). Conclusion Detection of antibacterial activity and isolation of an antibacterial compound, camaric acid, from extracts of ssp. var. supports the traditional use of extracts of the plant for treatment of gastrointestinal problems. Betulinic acid and camaric acid are already established to have anticancer activity.	en_US
dc.identifier.citation	Innocent, E., Nondo, R.S., Moshi, M.J. and Shah, T., 2011. Antibacterial and cytotoxic triterpenoids from Lantana viburnoides ssp. viburnoides var. kisi. Spatula DD-Peer Reviewed Journal on Complementary Medicine and Drug Discovery, 1(4), pp.213-218.	en_US
dc.identifier.other	DOI 10.5455/spatula.20111207111650
dc.identifier.uri	http://hdl.handle.net/123456789/1125
dc.language.iso	en	en_US
dc.publisher	Spatula DD-Peer Reviewed Journal on Complementary Medicine and Drug Discovery	en_US
dc.subject	Betulinic acid	en_US
dc.subject	Antibacterial	en_US
dc.subject	Camaric acid	en_US
dc.title	Antibacterial and cytotoxic triterpenoids from Lantana viburnoides ssp. viburnoides var. kisi	en_US
dc.type	Article	en_US