Immunoglobulin G (IgG) Responses to Plasmodium falciparum Glycosylphosphatidylinositols Are Short-Lived and Predominantly of the IgG 3 Subclass

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dc.contributor.authorMgone, Charles S.
dc.date.accessioned2020-03-17T13:05:08Z
dc.date.available2020-03-17T13:05:08Z
dc.date.issued2003
dc.description.abstractThe induction of neutralizing immunity to Plasmodium falciparum toxins by vaccination has been proposed as a preventive strategy to limit the severity of malaria. For this approach to be successful, generation of a sustained immune response would be necessary. This study shows that immunoglobulin G (IgG)–subclass responses elicited by the proposed P. falciparum toxin glycosylphosphatidylinositol (GPI) in Papua New Guinean subjects 5–60 years old predominantly involve IgG3, with a lesser contribution from IgG1 and an absence of IgG2 and IgG4. IgG3 levels declined sharply within 6 weeks of pharmacological clearance of parasitemia in all subjects, whereas a significant decrease in IgG1 levels was seen only in subjects ⩽19 years old. Because the natural antibody response to P. falciparum GPIs is skewed toward the short-lived IgG3 subclass, a vaccination strategy with GPI analogues would likely require augmentation by costimulatory molecules, to induce a more persistent anti-GPI responseen_US
dc.identifier.citationBoutlis, C.S., Fagan, P.K., Gowda, D.C., Lagog, M., Mgone, C.S., Bockarie, M.J. and Anstey, N.M., 2003. Immunoglobulin G (IgG) responses to Plasmodium falciparum glycosylphosphatidylinositols are short-lived and predominantly of the IgG3 subclass. The Journal of infectious diseases, 187(5), pp.862-865.en_US
dc.identifier.otherdoi.org/10.1086/367897
dc.identifier.urihttp://hdl.handle.net/123456789/367
dc.language.isoenen_US
dc.publisherThe Journal of infectious diseasesen_US
dc.subjectAntibody formationen_US
dc.subjectImmune responseen_US
dc.subjectDrug clearanceen_US
dc.titleImmunoglobulin G (IgG) Responses to Plasmodium falciparum Glycosylphosphatidylinositols Are Short-Lived and Predominantly of the IgG 3 Subclassen_US
dc.typeArticleen_US

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