Antimycobacterial activity and brine shrimp toxicity of wild mushrooms used by communities in southern Tanzania
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Date
2024-03-12
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Research Journal of Pharmacognosy
Abstract
Background and objectives: Several wild mushroom species occur in southern Tanzania and are
used as food by the local tribes. Experience shows that some of them could contain phytochemical
compounds with therapeutic potential for treating various diseases. This study aimed to evaluate wild
mushrooms used by indigenous communities living near the Selous- Niassa corridor in Namtumbo
district, in Southern Tanzania for safety and antimycobacterial activity. Methods: Wild mushroom
samples were collected randomly during the wet season and extracted by cold maceration. Dried
extracts were evaluated for safety using the brine shrimp lethality test and for antimycobacterial
activity using a twofold microdilution method against non-pathogenic Mycobacterium
madagascariense, Mycobacterium indicus pranii, and Mycobacterium aurum. Results: The
mushroom extracts exhibited a good safety profile against brine shrimp larvae with LC50 values
ranging from 20.28 µg/mL (moderately toxic) to 465.97 µg/mL (nontoxic). The extracts exhibited
variable antimycobacterial activity against M. madagascariense, M. indicus pranii, and M. aurum
with minimum inhibitory concentrations (MIC) between 0.78 and 12.5 mg/mL against M.
madagascariense, 0.098 and 6.25 mg/mL against M. indicus pranii and 1.25 and 2.5 mg/mL against
and M. aurum. Nineteen wild mushroom species (59.4%, n = 32) exhibited antimycobacterial activity
against all three mycobacterial species used. Conclusion: Preliminary investigation has provided
evidence that some of the mushrooms locally available are not toxic. Some of these mushrooms have
the potential to yield antimicobacterial active compounds. Further studies to determine the therapeutic
and nutritional value of these mushrooms are needed.
Keywords: anti-mycobacterial; brine shrimp lethality test; therapeutic potential; wild mushrooms
Description
Keywords
Anti-mycobacterial, Brine shrimp lethality test, Therapeutic potential
Citation
Qwarse, M., Moshi, M.J., Mihale, M.J., Marealle, A.I., Nondo, R.S.O., Sempombe, J. and Mugoyela, V., Antimycobacterial activity and brine shrimp toxicity of wild mushrooms used by communities in Southern Tanzania. Res J Pharmacogn. 2024; 11 (2): 37–46. Qwarse M. et al, 38, pp.37-46.