Maternal disease stage and child undernutrition in relation to mortality among children born to HIV-infected women in Tanzania

Fataki, Maulidi R.

Maternal disease stage and child undernutrition in relation to mortality among children born to HIV-infected women in Tanzania

dc.contributor.author	Fataki, Maulidi R.
dc.date.accessioned	2020-10-26T05:50:04Z
dc.date.available	2020-10-26T05:50:04Z
dc.date.issued	2007
dc.description.abstract	Objective: To examine whether maternal HIV disease stage during pregnancy and child malnutrition are associated with child mortality. Design: Prospective cohort study in Tanzania. Methods: Indicators of disease stage were assessed for 939 HIV-infected women during pregnancy and at delivery, and children's anthropometric status was obtained at scheduled monthly clinic visits after delivery. Children were followed up for survival status until 24 months after birth. Results: Advanced maternal HIV disease during pregnancy (CD4 count <350 vs. ≥350 cells/mm3) was associated with increased risk of child mortality through 24 months of age (hazard ratio [HR] = 1.74, 95% confidence interval [CI]: 1.32 to 2.30). CD4 count <350 cells/mm3 was also associated with an increased risk of death among children who remained HIV-negative during follow-up (HR = 2.00, 95% CI: 1.36 to 2.94). Low maternal hemoglobin concentration and child undernutrition were related to an increased risk of mortality in this cohort of children. Conclusions: Low maternal CD4 cell count during pregnancy is related to increased risk of mortality in children born to HIV-infected women. Care and treatment for HIV disease, including highly active antiretroviral therapy to pregnant women, could improve child survival. Prevention and treatment of undernutrition in children remain critical interventions in settings with high HIV prevalence.	en_US
dc.identifier.citation	Chatterjee, A., Bosch, R.J., Hunter, D.J., Fataki, M.R., Msamanga, G.I. and Fawzi, W.W., 2007. Maternal disease stage and child undernutrition in relation to mortality among children born to HIV-infected women in Tanzania. JAIDS Journal of Acquired Immune Deficiency Syndromes, 46(5), pp.599-606.	en_US
dc.identifier.other	doi: 10.1097/QAI.0b013e31815a5703
dc.identifier.uri	http://hdl.handle.net/123456789/712
dc.language.iso	en	en_US
dc.publisher	JAIDS Journal of Acquired Immune Deficiency Syndromes	en_US
dc.subject	CD4	en_US
dc.subject	Child mortality	en_US
dc.subject	HIV	en_US
dc.title	Maternal disease stage and child undernutrition in relation to mortality among children born to HIV-infected women in Tanzania	en_US
dc.type	Article	en_US