Insulin Resistance and Hypertension in Non-obese Africans in Tanzania
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Date
1998
Authors
Journal Title
Journal ISSN
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Publisher
Hypertension
Abstract
Abstract—Insulin sensitivity was assessed using a glucose-insulin infusion test in 15 newly diagnosed non-obese hypertensive black Tanzanians with normal glucose tolerance and in 15 normotensive control subjects matched for age, sex, and body mass index. The steady-state blood glucose and metabolic clearance rate of glucose (MCR) were used as measures of insulin sensitivity. The mean MCR (glucose) was significantly reduced (7.12±0.57 versus 9.50±0.69 μmol/kg per minute; P<.05) and mean steady-state blood glucose was significantly elevated (5.0±0.3 versus 3.7±0.3 mmol/L; P<.01) in subjects with hypertension compared with the normotensive group. For all subjects there was a significant inverse correlation between MCR (glucose) and systolic (P=.003) and diastolic (P=.005) blood pressure; and a positive correlation was found between fasting serum insulin levels and systolic (P=.005) and diastolic (P=.004) blood pressure. These observations were independent of body mass index and serum lipid levels. These data indicate a strong association between insulin mediated glucose uptake and blood pressure in this population of normal weight untreated urban Africans.
Description
Keywords
Blood pressure, Africans, Insulin resistance
Citation
Mgonda, Y.M., Ramaiya, K.L., Swai, A.B., McLarty, D.G. and Alberti, K.G.M., 1998. Insulin resistance and hypertension in non-obese Africans in Tanzania. Hypertension, 31(1), pp.114-118.