Nitric Oxide, Malaria, and Anemia: Inverse Relationship between nitric Oxide Production and Hemoglobin Concentration in symptomatic, Malaria-Exposed Children
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Date
1999
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Anstey, N.M., Granger, D.L., Hassanali, M.Y., Mwaikambo, E.D., Duffy, P.E. and Weinberg, J.B., 1999. Nitric oxide, malaria, and anemia: inverse relationship between nitric oxide production and hemoglobin concentration in asymptomatic, malaria-exposed children. The American journal of tropical medicine and hygiene, 61(2), pp.249-252.
Abstract
Abstract
The cause of the anemia associated with chronic, intermittent, asymptomatic, low-level
parasitemia in children in malaria-endemic endemic areas is not well understood. Nitric oxide
(NO) decreases erythropoiesis, and it is likely an important mediator of anemia of chronic disease.
Production of NO is decreased in acute uncomplicated and cerebral malaria, but it is increased in
asymptomatic Tanzanian children (with or without parasitemia). We hypothesized that chronic
overproduction of NO in these asymptomatic children contributes to the anemia associated with
subclinical/subpatent malaria. In 44 fasting, asymptomatic, malaria-exposed, Tanzanian children,
NO production (measured using fasting urine NOx excretion) was inversely associated with
hemoglobin concentration (P = 0.03, controlling for age and gender). Using multiple linear
regression, hemoglobin concentration was negatively associated with parasitemia (P = 0.005).
After controlling for age and parasitemia, NO was no longer an independent predictor of anemia.
One of the mechanisms of parasite-related anemia in such children may be through the adverse
hematologic effects of parasite-induced NO production
Description
Keywords
Malaria, anemia, Nitric oxide
Citation
The American journal of tropical medicine and hygiene