Nitric Oxide, Malaria, and Anemia: Inverse Relationship between nitric Oxide Production and Hemoglobin Concentration in symptomatic, Malaria-Exposed Children

Mwaikambo, Esther D.

Nitric Oxide, Malaria, and Anemia: Inverse Relationship between nitric Oxide Production and Hemoglobin Concentration in symptomatic, Malaria-Exposed Children

dc.contributor.author	Mwaikambo, Esther D.
dc.date.accessioned	2020-10-22T12:32:20Z
dc.date.available	2020-10-22T12:32:20Z
dc.date.issued	1999
dc.description.abstract	Abstract The cause of the anemia associated with chronic, intermittent, asymptomatic, low-level parasitemia in children in malaria-endemic endemic areas is not well understood. Nitric oxide (NO) decreases erythropoiesis, and it is likely an important mediator of anemia of chronic disease. Production of NO is decreased in acute uncomplicated and cerebral malaria, but it is increased in asymptomatic Tanzanian children (with or without parasitemia). We hypothesized that chronic overproduction of NO in these asymptomatic children contributes to the anemia associated with subclinical/subpatent malaria. In 44 fasting, asymptomatic, malaria-exposed, Tanzanian children, NO production (measured using fasting urine NOx excretion) was inversely associated with hemoglobin concentration (P = 0.03, controlling for age and gender). Using multiple linear regression, hemoglobin concentration was negatively associated with parasitemia (P = 0.005). After controlling for age and parasitemia, NO was no longer an independent predictor of anemia. One of the mechanisms of parasite-related anemia in such children may be through the adverse hematologic effects of parasite-induced NO production	en_US
dc.identifier.citation	The American journal of tropical medicine and hygiene	en_US
dc.identifier.other	/doi.org/10.4269/ajtmh.1999.61.249
dc.identifier.uri	http://hdl.handle.net/123456789/699
dc.language.iso	en	en_US
dc.publisher	Anstey, N.M., Granger, D.L., Hassanali, M.Y., Mwaikambo, E.D., Duffy, P.E. and Weinberg, J.B., 1999. Nitric oxide, malaria, and anemia: inverse relationship between nitric oxide production and hemoglobin concentration in asymptomatic, malaria-exposed children. The American journal of tropical medicine and hygiene, 61(2), pp.249-252.	en_US
dc.subject	Malaria	en_US
dc.subject	anemia	en_US
dc.subject	Nitric oxide	en_US
dc.title	Nitric Oxide, Malaria, and Anemia: Inverse Relationship between nitric Oxide Production and Hemoglobin Concentration in symptomatic, Malaria-Exposed Children	en_US
dc.type	Article	en_US