Effect of Caesalpina Bonducella Seeds on Blood Glucose in Rabbits

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dc.contributor.authorMoshi, Mainen J.
dc.date.accessioned2023-08-11T05:44:26Z
dc.date.available2023-08-11T05:44:26Z
dc.date.issued2000-01-10
dc.description.abstractThe seeds of Caesalpinia bonducella (L.) Flem. (Cae-salpiniaceae) are sold in shops in Dar es Salaam,Tanzania, for the treatment of diabetes mellitus. A sus-pension of the powdered seed kernel in 0.5% car-boxymethylcellulose (CMC) was tested for ability tolower blood glucose in fasted and glucose-fed normalalbino rabbits. Following administration of 0.2, 0.4 and 0.8 g/kg body weight of the powder there was nodifference in areas under the fasting blood glucose andoral glucose tolerance test (OGTT) curves as com-pared to controls given CMC (P 0.05). Similarly, 0.2g/kg body weight of the powder administered for 7consecutive days had no effect on either fasting bloodglucose or the clearance of a glucose load from the blood. However, 0.1 g/kg body weight chlorpropamidesignificantly decreased the area under the fasting blood glucose and OGTT curves as compared to con-trols given CMC (P 0.05). Thus, contrary to a pre-vious report, we could not detect any hypoglycaemic activity in the seeds of Caesalpinia bonducella grow-ing in Dar es Salaamen_US
dc.identifier.citationMoshi, M.J. and Nagpa, V., 2000. Effect of Caesalpina Bonducella Seeds on Blood Glucose in Rabbits. Pharmaceutical biology, 38(2), pp.81-86.en_US
dc.identifier.otherhttps://doi.org/10.1076/1388-0209(200004)3821-1FT081
dc.identifier.urihttp://hdl.handle.net/123456789/1091
dc.language.isoenen_US
dc.publisherPharmaceutical biologyen_US
dc.subjectCaesalpinia bonducellaen_US
dc.subjectCaesalpiniaceaeen_US
dc.subjectRabbitsen_US
dc.titleEffect of Caesalpina Bonducella Seeds on Blood Glucose in Rabbitsen_US
dc.typeArticleen_US

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