A multivariate pattern analysis of resting-state functional MRI data in Naïve and chronic betel quid chewers.

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dc.contributor.authorSariah, Adellah
dc.date.accessioned2021-10-12T07:56:19Z
dc.date.available2021-10-12T07:56:19Z
dc.date.issued2020
dc.description.abstractBetel quid (BQ) is the fourth most commonly consumed psychoactive substance in the world. However, comprehensive functional magnetic resonance imaging (fMRI) studies exploring the neurophysiological mechanism of BQ addiction are lacking. Betel-quid-dependent (BQD) individuals (n = 24) and age-matched healthy controls (HC) (n = 26) underwent fMRI before and after chewing BQ. Multivariate pattern analysis (MVPA) was used to explore the acute effects of BQ-chewing in both groups. A cross-sectional comparison was conducted to explore the chronic effects of BQ-chewing. Regression analysis was used to investigate the relationship between altered circuits of BQD individuals and the severity of BQ addiction. MVPA achieved classification accuracies of up to 90% in both groups for acute BQ-chewing. Suppression of the default-mode network was the most prominent feature. BQD showed more extensive and intensive within- and between-network dysconnectivity of the default, frontal-parietal, and occipital regions associated with high-order brain functions such as self-awareness, inhibitory control, and decision-making. In contrast, the chronic effects of BQ on the brain function were mild, but impaired circuits were predominately located in the default and frontal-parietal networks which might be associated with compulsive drug use. Simultaneously quantifying the effects of both chronic and acute BQ exposure provides a possible neuroimaging-based BQ addiction foci. Results from this study may help us understand the neural mechanisms involved in BQ-chewing and BQ dependence.en_US
dc.description.sponsorshipHKMUen_US
dc.identifier.citationLinli, Z., Huang, X., Liu, Z., Guo, S. and Sariah, A., 2020. A multivariate pattern analysis of resting-state functional MRI data in Naive and chronic betel quid chewers. Brain Imaging and Behavior, pp.1-13.en_US
dc.identifier.otherhttps://doi.org/10.1007/s11682-020-00322-6
dc.identifier.urihttp://hdl.handle.net/123456789/767
dc.language.isoenen_US
dc.publisherBrain Imaging and Behavioren_US
dc.subjectAcute effecten_US
dc.subjectMultivariate pattern analysisen_US
dc.subjectChronic effecten_US
dc.titleA multivariate pattern analysis of resting-state functional MRI data in Naïve and chronic betel quid chewers.en_US
dc.typeArticleen_US

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