High rate of fatal cases of Pediatric Septicemia caused by Gram-Negative Bacteria with Extended-Spectrum Bjørn Blomberg, Beta-Lactamases in Dar es Salaam, Tanzania
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Date
2005
Authors
Journal Title
Journal ISSN
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Publisher
Journal of clinical microbiology
Abstract
Extended-spectrum beta-lactamases (ESBLs) were present in high proportions of Escherichia coli (25% [9 of 36]) and Klebsiella pneumoniae isolates (17% [9 of 52]) causing pediatric septicemia at a tertiary hospital in Tanzania. Patients with septicemia due to ESBL-producing organisms had a significantly higher fatality rate than those with non-ESBL isolates (71% versus 39%, P = 0.039). This is the first report of the CTX-M-15 genotype of ESBLs on the African continent and the first observation of SHV-12 genotype in an isolate of Salmonella enterica serotype Newport.
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Keywords
Pediatric Septicemia, Tanzania, Gram-Negative Bacteria
Citation
Blomberg, B., Jureen, R., Manji, K.P., Tamim, B.S., Mwakagile, D.S., Urassa, W.K., Fataki, M., Msangi, V., Tellevik, M.G., Maselle, S.Y. and Langeland, N., 2005. High rate of fatal cases of pediatric septicemia caused by gram-negative bacteria with extended-spectrum beta-lactamases in Dar es Salaam, Tanzania. Journal of clinical microbiology, 43(2), pp.745-749.