Mass spectrometric analysis of Plasmodium falciparum erythrocyte membrane protein‐1 variants expressed by placental malaria parasites

Mutabingwa, Theonest K.

Mass spectrometric analysis of Plasmodium falciparum erythrocyte membrane protein‐1 variants expressed by placental malaria parasites

dc.contributor.author	Mutabingwa, Theonest K.
dc.date.accessioned	2020-10-08T08:03:02Z
dc.date.available	2020-10-08T08:03:02Z
dc.date.issued	2004
dc.description.abstract	Surface proteins from Plasmodium falciparum are important malaria vaccine targets. However, the surface proteins previously identified are highly variant and difficult to study. We used tandem mass spectrometry to characterize the variant antigens (Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1)) expressed on the surface of malaria‐infected erythrocytes that bind to chondroitin sulfate A (CSA) in the placenta. Whereas PfEMP1 variants previously implicated as CSA ligands were detected, in unselected parasites four novel variants were detected in CSA‐binding or placental parasites but not in unselected parasites. These novel PfEMP1 variants require further study to confirm whether they play a role in placental malaria.	en_US
dc.identifier.citation	Fried, M., Wendler, J.P., Mutabingwa, T.K. and Duffy, P.E., 2004. Mass spectrometric analysis of Plasmodium falciparum erythrocyte membrane protein‐1 variants expressed by placental malaria parasites. Proteomics, 4(4), pp.1086-1093.	en_US
dc.identifier.other	https://doi.org/10.1002/pmic.200300666
dc.identifier.uri	http://hdl.handle.net/123456789/626
dc.language.iso	en	en_US
dc.publisher	Proteomics	en_US
dc.subject	Plasmodium falciparum	en_US
dc.subject	Erythrocyte membrane protein‐1	en_US
dc.subject	Placental malaria parasites	en_US
dc.title	Mass spectrometric analysis of Plasmodium falciparum erythrocyte membrane protein‐1 variants expressed by placental malaria parasites	en_US
dc.type	Article	en_US