Plasmodium falciparum histidine-rich protein-2 (pHRP-2) is a cerebrospinal fluid (CSF) biomarker for cerebral malaria (CM)
Loading...
Date
2013
Journal Title
Journal ISSN
Volume Title
Publisher
Journal of the Neurological Sciences
Abstract
Abstract
Background: Cerebral malaria (CM) causes a rapidly developing comatose state and remains a
major contributor to morbidity and mortality in malaria-endemic regions. CM may be diagnosed
during life by the presence of Plasmodium/INS; falciparum parasitemia, clinical assessment and
retinal changes. The plasma level of pHRP-2, a malaria histidine- and alanine-rich protein,
identifies children with histologically confirmed or retinopathy-positive CM with high specificity
and sensitivity. We sought to determine whether pHRP-2 levels in the CSF were detectable in CM
cases
Description
Keywords
Plasmodium, Falciparum, Celebral Malaria
Citation
Thakur, K.T., Mikita, K., Piera, K., Pardo-Villamizar, C., Weinberg, J.B., Anstey, N.M., Mukemba, J., Florence, S., Mwaikambo, E.D., Granger, D.L. and Sullivan, D., 2013. Plasmodium falciparum histidine-rich protein-2 (pHRP-2) is a cerebrospinal fluid (CSF) biomarker for cerebral malaria (CM). Journal of the Neurological Sciences, 333, p.e697.