Characterization of genetic variation and natural selection at the arylamine N-acetyltransferase genes in global human populations.
| dc.contributor.author | Nyambo, Thomas B. | |
| dc.date.accessioned | 2023-09-26T05:57:23Z | |
| dc.date.available | 2023-09-26T05:57:23Z | |
| dc.date.issued | 2011-11-01 | |
| dc.description.abstract | Functional variability at the arylamine N-acetyltransferase genes is associated with drug response in humans and may have been adaptive in the past owing to selection pressure from diet and exposure to toxins during human evolution. Aims: We have characterized nucleotide variation at the NAT1 and NAT2 genes, and at the NATP1 pseudogene in global human populations, including many previously under-represented African populations, in order to identify potential functional variants and to understand the role that natural selection has played in shaping variation at these loci in globally diverse populations. Materials & methods: We have resequenced approximately 2800 bp for each of the NAT1 and NAT2 gene regions, as well as the pseudogene NATP1, in 197 African and 132 nonAfrican individuals. Results & conclusion: We observe a signature of balancing selection maintaining variation in the 3’-UTR of NAT1, suggesting that these variants may play a functional role that is currently undefined. In addition, we observed high levels of nonsynonymous functional variation at the NAT2 locus that differs amongst ethnically diverse populations. | en_US |
| dc.description.sponsorship | This work was supported by the US National Science Foundation (NSF) IGERT grant 9987590 to Holly M Mortensen and Sarah A Tishkoff, NSF grants BCS 0196183, and BCS-0827436, NIH grants R01GM076637 and DP1-OD-006445-01 to Sarah A Tishkoff. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. | en_US |
| dc.identifier.citation | Mortensen, H.M., Froment, A., Lema, G., Bodo, J.M., Ibrahim, M., Nyambo, T.B., Omar, S.A. and Tishkoff, S.A., 2011. Characterization of genetic variation and natural selection at the arylamine N-acetyltransferase genes in global human populations. Pharmacogenomics, 12(11), pp.1545-1558. | en_US |
| dc.identifier.uri | https://doi.org/10.2217/pgs.11.88 | |
| dc.identifier.uri | http://hdl.handle.net/123456789/1208 | |
| dc.language.iso | en | en_US |
| dc.publisher | Pharmacogenomics | en_US |
| dc.subject | Africa | en_US |
| dc.subject | Arylamine N-acetyltransferase | en_US |
| dc.subject | Drug-metabolizing Enzyme Loci | en_US |
| dc.title | Characterization of genetic variation and natural selection at the arylamine N-acetyltransferase genes in global human populations. | en_US |
| dc.type | Article | en_US |