Prevalence of HIV-1 infection and symptomatology of AIDS in severely malnourished children in Dar Es Salaam, Tanzania.

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dc.contributor.authorMgone, Charles S.
dc.date.accessioned2020-03-19T09:11:04Z
dc.date.available2020-03-19T09:11:04Z
dc.date.issued1991
dc.description.abstractIn Dar es Salaam, Tanzania, 200 children with severe malnutrition and controls matched for age, sex, and area of residence were screened for serological evidence of infection with the human immunodeficiency virus type 1 (HIV-1) over 5 months in 1988. The prevalence of HIV-1 antibodies in the malnourished group was 25.5% (51 of 200) compared with 1.5% (three of 200) in the controls. The seroprevalence rate was equally high in malnourished children above the age of 18 months (26 of 102; 25.5%), as in those below this age (25 of 98; 25.5%). The prevalence rate was higher in children with marasmus (38.2%) as compared to children with marasmic-kwashiorkor (12.3%) or kwashiorkor (12.2%). The prevalence of clinical features known to be associated with AIDS was higher in the HIV seropositive malnourished children as compared to the seronegative children. The modified World Health Organization clinical case definition of AIDS in children was also evaluated and found to have a low sensitivity and positive predictive value (62.8 and 57.1%, respectively) but a fairly high specificity (83.9%). It is recommended to routinely rule out HIV infection in malnourished children, especially those with marasmus.en_US
dc.identifier.citationMgone, C.S., Mhalu, F.S., Shao, J.F., Britton, S., Sandström, A., Bredberg-Råden, U. and Biberfeld, G., 1991. Prevalence of HIV-1 infection and symptomatology of AIDS in severely malnourished children in Dar Es Salaam, Tanzania. Journal of acquired immune deficiency syndromes, 4(9), pp.910-913.en_US
dc.identifier.otherhttps://europepmc.org/article/med/1910083
dc.identifier.urihttp://hdl.handle.net/123456789/373
dc.language.isoenen_US
dc.publisherJournal of acquired immune deficiency syndromesen_US
dc.subjectTanzaniaen_US
dc.subjectSymptomatologyen_US
dc.subjectHIV-1en_US
dc.titlePrevalence of HIV-1 infection and symptomatology of AIDS in severely malnourished children in Dar Es Salaam, Tanzania.en_US
dc.typeArticleen_US

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