Determinants of hyperleptinaemia in an African population.

Mashalla, Yohana J.

Determinants of hyperleptinaemia in an African population.

dc.contributor.author	Mashalla, Yohana J.
dc.date.accessioned	2022-04-06T11:24:04Z
dc.date.available	2022-04-06T11:24:04Z
dc.date.issued	2003-02-17
dc.description.abstract	Objective: To examine the determinants for elevated plasma leptin concentration in normal weight (NW), obese (OB), and morbidly obese (MO) individuals in Tanzania. Design: Cross-sectional epidemiological study, the CARDIAC study. Setting: Three areas in Tanzania; Dar es Salaam, urban(U), Handeni, rural(R) and Monduli, pastoralists(P), in August 1998. Subjects: Five hundred and forty five participants from a random sample of 600 people aged 46-58 years. Main outcome measures: Plasma leptin concentrations, height, weight, body mass index (BMI), lipid profiles, haemoglobin Alc (HBA1c), and blood pressure (BP). Results: Plasma leptin concentrations were higher in women than in men (women; 16.0 ng/ mL, men; 3.1 ng/mL; p<0.0001). Women showed a higher mean body mass index (BMI), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) than men. In both genders, plasma leptin concentration, total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), triglycerides (TG), systolic BP (SBP) and diastolic BP (DBP) were significantly higher in OB than in NW participants. MO women had significantly higher leptin concentration, SBP and DBP compared with the other two groups. In NW men, log leptin concentrations showed a direct correlation with weight, BMI, HBAlc, TC, LDL-C, TG, SBP and DBP (all p<0.0001 except TG; p<0.001), while among NW women and OB men, weight and BMI correlated positively with log leptin (all p<0.05). OB women observed a positive correlation between log leptin and weight, BMI and LDL-C. Regression analysis indicated that among NW subjects, gender, BMI and TC explained 53.9% of the variation in log leptin. In OB subjects, gender, BMI and LDL-C explained 51.7% of the variability in leptin levels. No relationship was found between log leptin and CVD risk factors among MO subjects. Conclusion: The most important determinants for hyperleptinaemia in NW participants were gender, BMI, TC, while in addition to these LDL-C, was an important determinant of leptin concentration in OB individuals. In MO women, the high leptin concentrations did not reflect the amount of adipose stores.	en_US
dc.identifier.citation	Njelekela, M., Kuga, S., Hiraoka, J., Masesa, Z., Ntogwisangu, J., Mashalla, Y., Ikeda, K., Mtabaji, J., Nara, Y., Yamori, Y. and Tsuda, K., 2003. Determinants of hyperleptinaemia in an African population. East African medical journal, 80(4), pp.195-199.	en_US
dc.identifier.other	DOI: 10.4314/eamj.v80i4.8641
dc.identifier.uri	http://hdl.handle.net/123456789/965
dc.language.iso	en	en_US
dc.publisher	East African medical journal	en_US
dc.subject	Hyperleptinaemia	en_US
dc.subject	African	en_US
dc.subject	Population	en_US
dc.title	Determinants of hyperleptinaemia in an African population.	en_US
dc.type	Article	en_US