Decreased Microvascular Function in Tanzanian Children With Severe and Uncomplicated Falciparum Malaria

Simple item page
dc.contributor.authorKalabamu, Florence S.
dc.contributor.authorKalingonji, Ayam R.
dc.contributor.authorMwaikambo, Esther D.
dc.date.accessioned2020-02-14T05:26:43Z
dc.date.available2020-02-14T05:26:43Z
dc.date.issued2017
dc.description.abstractMicrovascular function and oxygen consumption affect oxygen homeostasis but have not been assessed in African children with malaria. Microvascular function in Tanzanian children with severe malaria (SM) or uncomplicated malaria were 39% and 72%, respectively, of controls (P < .001). Uncomplicated malaria (P = .04), not SM (P = .06), children had increased oxygen consumption compared with controls. A major pathogenic mechanism in severe falciparum malaria is microcirculatory obstruction due to parasite sequestration [1]. However, several studies suggest that sequestration alone may not impair microcirculatory flow in malaria [1–3]. The normal microvasculature matches oxygen delivery and demand, with a major mediator being nitric oxide (NO) [2, 4]. In malaria, NO pathway dysregulation impairs host NO production and bioavailability [5–8]. In Indonesian children, vascular NO and microvascular function was decreased in severe and uncomplicated falciparum malaria [3]. Oxygen demand may exacerbate tissue hypoxia and was increased in Indonesian adults and children with malaria [2, 3]. However, microvascular function and oxygen demand have not been assessed in African children, the group with the highest burden of malaria. We assessed skeletal muscle microvascular function and oxygen consumption in Tanzanian children with severe malaria (SM) or uncomplicated malaria (UM) and compared these to controls.en_US
dc.identifier.citationYeo, T.W., Florence, S.M., Kalingonji, A.R., Chen, Y., Granger, D.L., Anstey, N.M., Mwaikambo, E.D. and Weinberg, J.B., 2017, April. Decreased microvascular function in Tanzanian children with severe and uncomplicated falciparum malaria. In Open forum infectious diseases (Vol. 4, No. 2). Oxford University Press.en_US
dc.identifier.otherhttps://doi.org/10.1093/ofid/ofx079
dc.identifier.urihttp://hdl.handle.net/123456789/214
dc.language.isoenen_US
dc.publisherOpen Forum Infectious Diseasesen_US
dc.subjectMicrovascular functionen_US
dc.subjectPlasmodium falciparumen_US
dc.subjectSevere malaria.en_US
dc.titleDecreased Microvascular Function in Tanzanian Children With Severe and Uncomplicated Falciparum Malariaen_US
dc.typeArticleen_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Decreased Microvascular Function in Tanzanian Children With Severe and Uncomplicated Falciparum Malaria.pdf
Size:
117.4 KB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Journals

Total Collections: 1