Antiparasitic Activity of Some xanthones and biflavonoids from the root bark of garcinia livingstonei
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Date
2006
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Publisher
Journal of natural products
Abstract
A new biflavanoid, ent-naringeninyl-(I-3α,II-8)-4‘-O-methylnaringenin (6), along with five known xanthones and two known biflavonoids, was isolated from the root bark of Garcinia livingstonei collected in Tanzania. The absolute configuration of 6 was established by CD spectroscopy. This compound showed moderate activity against P. falciparum (IC50 6.7 μM). Antitrypanosomal activity (IC50 0.87 μM) was observed for 1,4,5-trihydroxy-3-(3-methylbut-2-enyl)-9H-xanthen-9-one (3). The dimeric xanthone garcilivin A (4) showed a higher and nonselective antiparasitic activity and cytotoxicity (IC50 2.0 μM against MRC-5 cells) than its diastereoisomer garcilivin C (5) (IC50 52.3 μM).
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Keywords
Antiparasitic Activity, Garcinia livingstonei, Xanthones and Biflavonoids
Citation
Mbwambo, Z.H., Kapingu, M.C., Moshi, M.J., Machumi, F., Apers, S., Cos, P., Ferreira, D., Marais, J.P., Vanden Berghe, D., Maes, L. and Vlietinck, A., 2006. Antiparasitic activity of some xanthones and biflavonoids from the root bark of Garcinia livingstonei. Journal of natural products, 69(3), pp.369-372.