Antiparasitic Activity of Some xanthones and biflavonoids from the root bark of garcinia livingstonei

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dc.contributor.authorMoshi, Mainen J.
dc.date.accessioned2023-08-11T05:43:23Z
dc.date.available2023-08-11T05:43:23Z
dc.date.issued2006
dc.description.abstractA new biflavanoid, ent-naringeninyl-(I-3α,II-8)-4‘-O-methylnaringenin (6), along with five known xanthones and two known biflavonoids, was isolated from the root bark of Garcinia livingstonei collected in Tanzania. The absolute configuration of 6 was established by CD spectroscopy. This compound showed moderate activity against P. falciparum (IC50 6.7 μM). Antitrypanosomal activity (IC50 0.87 μM) was observed for 1,4,5-trihydroxy-3-(3-methylbut-2-enyl)-9H-xanthen-9-one (3). The dimeric xanthone garcilivin A (4) showed a higher and nonselective antiparasitic activity and cytotoxicity (IC50 2.0 μM against MRC-5 cells) than its diastereoisomer garcilivin C (5) (IC50 52.3 μM).en_US
dc.identifier.citationMbwambo, Z.H., Kapingu, M.C., Moshi, M.J., Machumi, F., Apers, S., Cos, P., Ferreira, D., Marais, J.P., Vanden Berghe, D., Maes, L. and Vlietinck, A., 2006. Antiparasitic activity of some xanthones and biflavonoids from the root bark of Garcinia livingstonei. Journal of natural products, 69(3), pp.369-372.en_US
dc.identifier.otherhttps://doi.org/10.1021/np050406v
dc.identifier.urihttp://hdl.handle.net/123456789/1090
dc.language.isoenen_US
dc.publisherJournal of natural productsen_US
dc.subjectAntiparasitic Activityen_US
dc.subjectGarcinia livingstoneien_US
dc.subjectXanthones and Biflavonoidsen_US
dc.titleAntiparasitic Activity of Some xanthones and biflavonoids from the root bark of garcinia livingstoneien_US
dc.typeArticleen_US

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