Antiplasmodial Biflavanones from the Stem Bark of Garcinia buchananii Engl.
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Date
2019
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Publisher
Pharmacogn. Commn
Abstract
Introduction: Plants of the genus Garcinia are traditionally used treat a range of infectious and non-infectious diseases. Garcinia species are reported to have been shown to have a range of biological activities including cytotoxicity antimicrobial, antifungal, antioxidant, antimalarial and HIV-1 protease inhibitory activity among others. Methods: Solvent extraction was done using CH2Cl2: MeOH (1:1). Isolation was done using column chromatography with silica gel as the stationery phase and ethyl
acetate and n-hexane used as mobile phase in increasing polarity. Thin layer chromatography was used to monitor the isolation. Structure elucida-tion was done using nuclear magnetic resonance and mass spectroscopic techniques. Chloroquine resistant (W2) and chloroquine sensitive (D6) P. falciparum strains were used for antiplasmodial assay. Results: Further bioassay guided fractionation of a CH2Cl2: MeOH (1:1) extract of Garcinia buchananii led to the isolation of two already reported biavanones, isogar-cinol (1) and guttiferone (2) with promising antiplasmodial activity against a chloroquine resistant (W2) Plasmodium falciparum strain with an IC50 of 2.8 ± 0.90 µg/mL for compound 1 and IC50 of 3.94 ± 0.38 µg/mL for compound 2. Compounds 1 and 2 also exhibited moderate activity against the chloro-quine sensitive (D6) Plasmodium falciparum strain with IC50 of 7.03±0.60 and 10.64±4.50 µg/mL, respectively. Conclusion: The results provide proof
to support the use of G. buchananii by the indigenous community for anti-malarial therapy.
Key words: Garcinia buchananii, Isogarcinol, Guttiferone F, Antiplasmodial
activity
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Keywords
Garcinia buchananii, Isogarcinol, Antiplasmodial activity
Citation
Omole, R.A., Moshi, M.J., Heydenreich, M., Malebo, H.M., Gathirwa, J.W., Oriko, R.O., Omosa, L.K. and Midiwo, J.O., 2019. Antiplasmodial Biflavanones from the Stem Bark of Garcinia buchananii Engl.