Antiplasmodial Biflavanones from the Stem Bark of Garcinia buchananii Engl.
| dc.contributor.author | Moshi, Mainen J. | |
| dc.date.accessioned | 2023-08-15T09:31:21Z | |
| dc.date.available | 2023-08-15T09:31:21Z | |
| dc.date.issued | 2019 | |
| dc.description.abstract | Introduction: Plants of the genus Garcinia are traditionally used treat a range of infectious and non-infectious diseases. Garcinia species are reported to have been shown to have a range of biological activities including cytotoxicity antimicrobial, antifungal, antioxidant, antimalarial and HIV-1 protease inhibitory activity among others. Methods: Solvent extraction was done using CH2Cl2: MeOH (1:1). Isolation was done using column chromatography with silica gel as the stationery phase and ethyl acetate and n-hexane used as mobile phase in increasing polarity. Thin layer chromatography was used to monitor the isolation. Structure elucida-tion was done using nuclear magnetic resonance and mass spectroscopic techniques. Chloroquine resistant (W2) and chloroquine sensitive (D6) P. falciparum strains were used for antiplasmodial assay. Results: Further bioassay guided fractionation of a CH2Cl2: MeOH (1:1) extract of Garcinia buchananii led to the isolation of two already reported biavanones, isogar-cinol (1) and guttiferone (2) with promising antiplasmodial activity against a chloroquine resistant (W2) Plasmodium falciparum strain with an IC50 of 2.8 ± 0.90 µg/mL for compound 1 and IC50 of 3.94 ± 0.38 µg/mL for compound 2. Compounds 1 and 2 also exhibited moderate activity against the chloro-quine sensitive (D6) Plasmodium falciparum strain with IC50 of 7.03±0.60 and 10.64±4.50 µg/mL, respectively. Conclusion: The results provide proof to support the use of G. buchananii by the indigenous community for anti-malarial therapy. Key words: Garcinia buchananii, Isogarcinol, Guttiferone F, Antiplasmodial activity | en_US |
| dc.identifier.citation | Omole, R.A., Moshi, M.J., Heydenreich, M., Malebo, H.M., Gathirwa, J.W., Oriko, R.O., Omosa, L.K. and Midiwo, J.O., 2019. Antiplasmodial Biflavanones from the Stem Bark of Garcinia buchananii Engl. | en_US |
| dc.identifier.other | DOI: 10.5530/pc.2019.3.20. | |
| dc.identifier.uri | http://hdl.handle.net/123456789/1155 | |
| dc.language.iso | en | en_US |
| dc.publisher | Pharmacogn. Commn | en_US |
| dc.subject | Garcinia buchananii | en_US |
| dc.subject | Isogarcinol | en_US |
| dc.subject | Antiplasmodial activity | en_US |
| dc.title | Antiplasmodial Biflavanones from the Stem Bark of Garcinia buchananii Engl. | en_US |
| dc.type | Article | en_US |