Antimicrobial and brine shrimp lethality of extracts of Terminalia mollis Laws
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Date
2006
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Publisher
African Journal of Traditional, Complementary and Alternative Medicines
Abstract
Using the disc diffusion method it was demonstrated that extracts of the
leaves, stem and roots of Terminalia mollis Laws (Combretaceae) have antibacterial
activity against Staphylococcus aureus (NCTC 6571), Escherichia coli (NCTC 10418),
Pseudomonas aeruginosa (NCTC 10662), Klebsiella pneumoniae (NCTC 9633), Salmonella
typhi (NCTC 8385), and Bacillus anthracis (NCTC 10073) and antifungal activity
against Candida albicans (Strain HG 392), and local strains of Aspergillus flavus and
Cryptococcus neoformans. The root extracts were the most active followed by the stem,
and leaf extracts. Extracts of the three parts also exhibited cytotoxicity to brine
shrimp larvae with LC50 values ranging from 26.3 to 58.1, l0.4 to 69.5, and 42.9‐
101.3μg/ml, for the root, stem, and leaf extracts, respectively. The results support the
traditional uses of extracts of this plant for the management of bacterial and fungal
infections.
Key words: Terminalia mollis, Antimicrobial activity, Traditional medicine.
Description
Keywords
Terminaliamollis, Antimicrobial activity, Traditionalmedicine
Citation
Moshi, M.J., Mbwambo, Z.H., Kapingu, M.C., Mhozya, V.H. and Marwa, C., 2006. Antimicrobial and brine shrimp lethality of extracts of Terminalia mollis Laws. African Journal of Traditional, Complementary and Alternative Medicines, 3(3), pp.59-69.