99mTc sestamibi scintimammography in the diagnosis of palpable breast masses
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Date
2003
Authors
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Publisher
Clinical trial
Abstract
Summary
The aim of this prospective study was to evaluate the diagnostic performance of 99m Tc sestamibi
scintimammography in a region with a low incidence of breast cancer (East, central and West Africa) and
to verify the clinical usefulness of this technique in identifying benign breast diseases. Thirty-eight women
(age range 22±38 years) with palpable breast masses (n = 38) and inconclusive mammograms were
included. Prone scintimammography was performed 10 min and 60±90 min in all patients after injection
using an isotime acquisition of 10 min. A positive scan for breast cancer was defined as tracer uptake on
the 10 min image and retention of activity on the 60±90 min image. A negative scan was defined as uptake
on the 10 min image and complete washout of activity on the 60±90 min image. All patients subsequently
underwent excisional biopsy of the breast masses and histological confirmation of the pathology. The
results of scintimammography and histopathology were in agreement in all patients, revealing 36 benign
lesions and two malignant lesions. Histopathologically, the lesions were fibroadenomas (27), fibrocystic
disease (five), abscesses (four) and invasive intraductal carcinoma (two). It is concluded that, in regions
with high incidence of benign breast diseases in young women, 99m Tc sestamibi scintimammography can
be used to rapidly characterize benign and malignant breast masses and thereby give priority to the
management of those with a serious condition. (# 2003 Lippincott Williams & Wilkins)
Keywords: benign, breast disease, fibroadenomas, palpable, scintimammography
Description
Keywords
Breast disease, Scintimammography, Palpable
Citation
Maunda KY, Chande H, Mselle TF, Bomanji JB. 99mTc sestamibi scintimammography in the diagnosis of palpable breast masses. Nucl Med Commun. 2003 Feb;24(2):141-4. doi: 10.1097/00006231-200302000-00006. PMID: 12548038.