Beneficial Effects of Omega-3 Polyunsaturated Fatty Acids in Gestational Diabetes: Consequences in Macrosomia and Adulthood Obesity.
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Date
2015-04-16
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Journal ISSN
Volume Title
Publisher
Journal of diabetes research
Abstract
Omega-3 polyunsaturated fatty acids (PUFAs) are increasingly being used to prevent cardiovascular diseases, including diabetes and obesity. In this paper, we report data on the observed effects of omega-3 PUFA on major metabolic disorders and immune system disruption during gestational diabetes and their consequences on macrosomia.While controversies still exist about omega 3 PUFA effects on antioxidant status regarding the level of omega-3PUFA in diet supplementation, their lipid-lowering effects are unanimously recognized by researchers. Animal studies have shown that omega-3 PUFA contributes to the maintenance of the immune defense system by promoting the differentiation of T helper (Th) cell to a Th2 phenotype in diabetic pregnancy and by shifting the Th1/Th2 ratio from a deleterious pro inflammatory Th1 phenotype to a protective anti-inflammatory Th2 phenotype in macrosomia and in adulthood obesity that results from macrosomia at birth. Based on the available evidence, international nutritionalandfoodagenciesrecommendadministrationofomega-3PUFAastriglyceride-loweringagents,for the preventionof cardiovascular disease risk and during human pregnancy and lactation.Furthermore,studies targeting humans are still required to explore application of the fatty acids as supplement in the management of gestational diabetes and inflammatory and immune diseases.
Description
Keywords
Omega-3, Diabetes, Obersity
Citation
Yessoufou, A., Nekoua, M.P., Gbankoto, A., Mashalla, Y. and Moutairou, K., 2015. Beneficial effects of omega-3 polyunsaturated fatty acids in gestational diabetes: consequences in macrosomia and adulthood obesity. Journal of diabetes research, 2015.