Beneficial Effects of Omega-3 Polyunsaturated Fatty Acids in Gestational Diabetes: Consequences in Macrosomia and Adulthood Obesity.

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dc.contributor.authorMashalla, Yohana J.
dc.date.accessioned2022-04-06T10:01:54Z
dc.date.available2022-04-06T10:01:54Z
dc.date.issued2015-04-16
dc.description.abstractOmega-3 polyunsaturated fatty acids (PUFAs) are increasingly being used to prevent cardiovascular diseases, including diabetes and obesity. In this paper, we report data on the observed effects of omega-3 PUFA on major metabolic disorders and immune system disruption during gestational diabetes and their consequences on macrosomia.While controversies still exist about omega 3 PUFA effects on antioxidant status regarding the level of omega-3PUFA in diet supplementation, their lipid-lowering effects are unanimously recognized by researchers. Animal studies have shown that omega-3 PUFA contributes to the maintenance of the immune defense system by promoting the differentiation of T helper (Th) cell to a Th2 phenotype in diabetic pregnancy and by shifting the Th1/Th2 ratio from a deleterious pro inflammatory Th1 phenotype to a protective anti-inflammatory Th2 phenotype in macrosomia and in adulthood obesity that results from macrosomia at birth. Based on the available evidence, international nutritionalandfoodagenciesrecommendadministrationofomega-3PUFAastriglyceride-loweringagents,for the preventionof cardiovascular disease risk and during human pregnancy and lactation.Furthermore,studies targeting humans are still required to explore application of the fatty acids as supplement in the management of gestational diabetes and inflammatory and immune diseases.en_US
dc.identifier.citationYessoufou, A., Nekoua, M.P., Gbankoto, A., Mashalla, Y. and Moutairou, K., 2015. Beneficial effects of omega-3 polyunsaturated fatty acids in gestational diabetes: consequences in macrosomia and adulthood obesity. Journal of diabetes research, 2015.en_US
dc.identifier.otherhttps://doi.org/10.1155/2015/731434
dc.identifier.urihttp://hdl.handle.net/123456789/963
dc.language.isoenen_US
dc.publisherJournal of diabetes researchen_US
dc.subjectOmega-3en_US
dc.subjectDiabetesen_US
dc.subjectObersityen_US
dc.titleBeneficial Effects of Omega-3 Polyunsaturated Fatty Acids in Gestational Diabetes: Consequences in Macrosomia and Adulthood Obesity.en_US
dc.typeArticleen_US

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