Existence of antimalarial formulations with low bioavailability in Tanzania

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dc.contributor.authorMassele, Amos Y.
dc.date.accessioned2022-01-19T13:01:30Z
dc.date.available2022-01-19T13:01:30Z
dc.date.issued2006
dc.description.abstractAbstract The main objective of this work was to assess the relative bioavailability of two tablet formulations containing sulfadoxine/pyrimethamine (SP) and marketed in Tanzania. Twelve healthy volunteers were randomized to receive a single oral dose of three SP tablets each containing 500 mg sulfadoxine (SDX) and 25 mg pyrimethamine (PYR) in a form of either A (a locally manufactured SP tablet formulation, manufactured by a local pharmaceutical industry in Tanzania) or B (Fansidar®, Hoffmann La Roche, Basel, Switzerland, an innovator's SP) after an overnight fasting. Serial blood samples (100 μL) were collected from a finger prick in duplicate up to 10 days and dried on Whatman® filter paper. The samples were assayed for SDX and PYR using high-performance liquid chromatographic methods. Pharmacokinetic parameters of SDX and PYR were estimated by single compartment method. The pharmacokinetics of formulation A - maximum plasma concentration, the areas under the plasma concentration - time curve and the relative bioavailability (A versus B) were significantly lower than those of formulation B (P<0.1). These observed differences indicate bioinequivalence between the two products.en_US
dc.identifier.citationMinzi, O.M., Massele, A., Justin-Temu, M., Ericsson, Ö. and Gustafsson, L.L., 2006. Existence of antimalarial formulations with low bioavailability in Tanzania. Tropical doctor, 36(2), pp.93-97.en_US
dc.identifier.otherdoi.org/10.1258/004947506776593512
dc.identifier.urihttp://hdl.handle.net/123456789/862
dc.language.isoenen_US
dc.publisherTropical doctoren_US
dc.subjectAntimalarialen_US
dc.subjectsulfadoxineen_US
dc.subjectPyrimethamineen_US
dc.titleExistence of antimalarial formulations with low bioavailability in Tanzaniaen_US
dc.typeArticleen_US

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