Plasma Levels of Apoliporptoein A1 in Malaria-Exposed Primigravidae Are Associated with Severe Anemia

Mutabingwa, Theonest K.

Plasma Levels of Apoliporptoein A1 in Malaria-Exposed Primigravidae Are Associated with Severe Anemia

dc.contributor.author	Mutabingwa, Theonest K.
dc.date.accessioned	2020-03-11T08:39:16Z
dc.date.available	2020-03-11T08:39:16Z
dc.date.issued	2010
dc.description.abstract	Background: Plasmodium falciparum placental malaria (PM) contributes to 10,000 maternal deaths due to severe anemia (SA) each year in Africa, primarily among primigravid women who are most susceptible. Increased levels of proinflammatory cytokines like TNF-α are associated with maternal anemia in first time mothers but not in other women. Here we aimed to identify additional changes in the plasma proteome associated with pregnancy malaria that may contribute to the development of malaria-related maternal anemia. Principal Findings:A semi-quantitative mass spectrometry approach was used to compare the relative abundance of plasma proteins in anemic versus non-anemic women with PM. Levels of 24 proteins differed significantly between anemic and non-anemic primigravidae, including several lipid metabolism proteins and molecular transport proteins involved in the acute phase response signaling network. These differences were not observed in multigravid women who enjoy specific immunity that protect them from PM. In a confirmatory study of a larger cohort of primigravid women, levels of the lipid metabolism protein Apolipoprotein (Apo)-AI were significantly lower in PM+ women with SA. Conclusions:Apo-AI levels are significantly lower in severely anemic primigravidae with PM, and ApoA1 levels positively correlate with hemoglobin levels in primigravid but not multigravid women. Apo-AI is known to have anti-inflammatory effects, and thus Apo-AI reductions may contribute to the inflammatory processes that result in SA.	en_US
dc.identifier.citation	Simpson, D.C., Kabyemela, E., Muehlenbachs, A., Ogata, Y., Mutabingwa, T.K., Duffy, P.E. and Fried, M., 2010. Plasma levels of Apoliporptoein A1 in malaria-exposed primigravidae are associated with severe anemia. PloS one, 5(1).	en_US
dc.identifier.other	doi: 10.1371/journal.pone.0008822
dc.identifier.uri	http://hdl.handle.net/123456789/325
dc.language.iso	en	en_US
dc.publisher	PloS one	en_US
dc.subject	Plasma	en_US
dc.subject	Malaria	en_US
dc.subject	Anemia	en_US
dc.title	Plasma Levels of Apoliporptoein A1 in Malaria-Exposed Primigravidae Are Associated with Severe Anemia	en_US
dc.type	Article	en_US