Prevalence and factors associated with asymptomatic hypoglycemia among preterm newborns in dar es salaam regional referral hospitals, tanzania: a cross sectional analytical study protocol
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Date
2022-10-30
Journal Title
Journal ISSN
Volume Title
Publisher
MedRxiv
Abstract
Background: Hypoglycemia is the most common metabolic abnormality in newborns. It is still unclear
whether the condition is truly pathological, especially if it occurs transiently during the 1st 24 hours
of birth in an asymptomatic phase. Besides, there is hardly any data on the burden of asymptomatic
neonatal hypoglycemia and its associated factors among preterm newborns in Africa.
Aim: To assess the prevalence and associated factors of asymptomatic neonatal hypoglycemia
among preterm newborns in a typical African settings.
Design and Methods: We plan to conduct a quick, cross-sectional analytical hospital-based survey at
all public regional referral hospitals in Dar es Salaam, Tanzania. We will consider all preterm
newborns delivered in the specified settings between June 2022 and December 2022. Our study
population will be all preterm newborns delivered at Dar es Salaam public regional referral hospitals.
Our target population will be all preterm newborns with asymptomatic hypoglycemia. All newborns
with clinically detected congenital anomalies and those who will be delivered at home but brought to
the facilities for care will thus be excluded from the study. Our primary outcome measure will be
neonatal RBG < 2.6 mmol/L without any symptoms associated with hypoglycemia. Maternal, fetal
and early neonatal (> 6 hours but within 24 hours post-delivery) factors will be logistically regressed
against the outcome variable after appropriate model validation. Unless otherwise stated, an α-level
of 5% will be used as a limit of type I error in findings. Written informed consent will be obtained
from mothers of each newborn prior to inclusion into the study.
Main Outcome measure: Prevalence of asymptomatic hypoglycemia among preterm newborns in
Dar es Salaam hospitals.
Relevance of the findings to science, policy & practice: Current clinical practice does not provide
evidence for routine glycaemic screening among preterm newborns asymptomatic for hypoglycemia.
The study will have a potential to assess stata of preterm newborn with asymptomatic hypoglycemia
Description
Keywords
Asymptomatic hypoglycemia, Neonates, Preterm
Citation
Salum, S.S., Kalabamu, F.S., Fataki, M.R., Omary, S.A., Mohamed, U.H., Kizwi, H.A. and Leshabari, K.M., 2022. PREVALENCE AND FACTORS ASSOCIATED WITH ASYMPTOMATIC HYPOGLYCEMIA AMONG PRETERM NEWBORNS IN DAR ES SALAAM REGIONAL REFERRAL HOSPITALS, TANZANIA: A CROSS SECTIONAL ANALYTICAL STUDY PROTOCOL. medRxiv, pp.2022-10.