Prenatal Exposure to Plasmodium Falciparum Lowers Humoral Responses during Clinical Malaria Episodes
| dc.contributor.author | Sylvester, Boniphace | |
| dc.date.accessioned | 2022-10-06T07:28:43Z | |
| dc.date.available | 2022-10-06T07:28:43Z | |
| dc.date.issued | 2018 | |
| dc.description.abstract | Prenatal exposure to Plasmodium falciparum infection affects the development of fetal immune cells in utero by inducing immunotolerance or immunosensitization of fetal immune cells to P.falciparum antigens. This study aimed at determining the effect of prenatal exposure to P.falciparum on specific humoral responses, with a focus on immunoglobulin M (IgM) and total IgG against blood stage Plasmodium falciparum merozoite surface protein 1 (PfMSP1-19) and Plasmodium falciparum merozoite surface protein2 (PfMSP2) during clinical malaria episodes in the first 24 months of life. A birth cohort study was conducted in Rufiji district, between January 2013 and June 2017. Infants (n=215) were recruited after delivery from mothers who were diagnosed of placental malaria (pm+) and without placental malaria (pm-). Total IgG against P.fMSP2 in peripheral blood of exposed and unexposed infants were 49.4 (95% CI 43.5-55.4) and 64.6 (95% CI 61.1-68.2) antibody units respectively, and the difference was statistically significant (P<0.01). The levels of IgM against PfMSP2 in exposed and unexposed infants during clinical malaria episodes were 47.9 (42.8-52.9) and 58.8 (56.1-61.6 respectively, and the difference was statistically significant (P<0.01). Prenatal exposure to Plasmodium falciparum modulates humoral immune response to specific Pf MSP1-19 and PfMSP2 with characteristically low total IgG and IgM in infants aged 0-2 years during clinical malaria episodes | en_US |
| dc.identifier.citation | Sylvester, B., Gasarasi, D.B., Aboud, S., Tarimo, D., Massawe, S., Mpembeni, R. and Swedberg, G., 2018. Prenatal Exposure to Plasmodium Falciparum Lowers Humoral Responses during Clinical Malaria Episodes. African Journal of Applied Research, 4(1), pp.52-61. | en_US |
| dc.identifier.other | http://doi.org/10.26437/ajar.04.01.2018.05 | |
| dc.identifier.uri | https://www.ajaronline.com/index.php/AJAR/article/view/248/191 | |
| dc.language.iso | en | en_US |
| dc.publisher | African Journal of Applied Research | en_US |
| dc.subject | Humoral | en_US |
| dc.subject | P.falciparum | en_US |
| dc.subject | Prenatal | en_US |
| dc.title | Prenatal Exposure to Plasmodium Falciparum Lowers Humoral Responses during Clinical Malaria Episodes | en_US |
| dc.type | Article | en_US |