The efficacy of tranexamic acid in the prevention of postpartum hemorrhage among women delivered by caesarean section: observational case control study
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Date
2023
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Hubert Kairuki Memorial University
Abstract
Background:
Postpartum hemorrhage is the key determinant of significant maternal death and
morbidity among women giving birth worldwide.
Objective:
To determine the effectiveness of Tranexamic acid premedication in the prevention of
Postpartum Hemorrhage
Methods:
This was an observational hospital-based case control study employing quantitative
approach to examine the efficacy of Tranexamic acid in prevention of Postpartum
Hemorrhage
Results:
Median (IQR) age of study participants was 28.8 (19-37) years. The study group
experienced significantly less blood loss than the control group, with 287 (110 - 409)
mls and 416 (307 - 688) mls respectively (P<0.001). Additionally, the study group
showed higher levels of hemoglobin (12.65 [10.3 – 13.5]) g/dL and hematocrit (34.9
[32 - 36]) 24 hours after the surgery compared to the standard of care group (10.6 [9.4
– 13.8] g/dLand 31.6 [28-34]) respectively (P<0.001). Median (IQR) of birth weights of
babies delivered by study participants was 2.99 (2.0 – 3.8) kg.
Conclusion:
Based on the results obtained, it appears that Tranexamic acid is probably more
effective in reducing Postpartum Hemorrhage
Description
A dissertation submitted to the faculty of Medicine in partial fulfillment of the requirements for the degree of Master of Medicine in Obstetrics and Gynecology of Hubert Kairuki Memorial University
Keywords
Postpartum hemorrhage, Tranexamic acid, Caesarean section
Citation
Furaha, Julius M., 2023. The efficacy of tranexamic acid in the prevention of postpartum hemorrhage among women delivered by caesarean section: observational case control study. HKMU