Malaria chemosuppression in pregnancy. II. Its effect on maternal haemoglobin levels, placental malaria and birth weight.

Mutabingwa, Theonest K.

Malaria chemosuppression in pregnancy. II. Its effect on maternal haemoglobin levels, placental malaria and birth weight.

dc.contributor.author	Mutabingwa, Theonest K.
dc.date.accessioned	2020-10-09T12:07:42Z
dc.date.available	2020-10-09T12:07:42Z
dc.date.issued	1993
dc.description.abstract	The malaria prophylactic effects of chloroquine (CQ), proguanil (PROG), and chloroquine-proguanil combination (CQ+PROG) during pregnancy on maternal haemoglobin levels (Hb), placental malaria, and birth weight were assessed in Muheza, Tanzania. Within 2 months of prophylaxis, severe anaemia in primigravidae (PG) was reduced from 21% (22 cases) to 13% (13 cases). There was no positive effect in multigravidae (MG). Sustained increases in the mean Hb occurred in PG of the PROG and CQ+PROG groups. The mean Hb of PG of the CQ group decreased after an initial increase, possibly due to the selection of more and highly chloroquine-resistant strain(s). The mean birth weight of PG was highest in the CQ+PROG (2.89 kg) and least in the CQ group (2.71 kg). The CQ group had the highest low birth weight rate (LBW). The prevalence of placental malaria was highest in the CQ (28%) and lowest in the PROG group (12%). For all the prophylactic effects, PROG and CQ+PROG did not differ significantly. Thence, the deployment of CQ+PROG for prophylaxis would be unnecessary. Proguanil is a suitable alternative to chloroquine prophylaxis. Due to possible emergence of proguanil resistance, deployment of this drug should incorporate constant monitoring for resistance and the eventual prophylaxis efficacy. The search for other effective malaria control measures should continue.	en_US
dc.identifier.citation	Mutabingwa, T.K., Malle, L.N., De Geus, A. and Oosting, J., 1993. Malaria chemosuppression in pregnancy. II. Its effect on maternal haemoglobin levels, placental malaria and birth weight. Tropical and geographical medicine, 45(2), pp.49-55.	en_US
dc.identifier.uri	https://europepmc.org/article/med/8511810#abstract
dc.identifier.uri	http://hdl.handle.net/123456789/639
dc.language.iso	en	en_US
dc.publisher	Tropical and geographical medicine	en_US
dc.subject	Haemoglobin levels	en_US
dc.subject	Malaria chemosuppression	en_US
dc.subject	Placental malaria	en_US
dc.title	Malaria chemosuppression in pregnancy. II. Its effect on maternal haemoglobin levels, placental malaria and birth weight.	en_US
dc.type	Article	en_US