A promoter polymorphism in the gene encoding interleukin-12 p40 (IL12B) is associated with mortality from cerebral malaria and with reduced nitric oxide production

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dc.contributor.authorMwaikambo, Esther D.
dc.date.accessioned2020-10-22T12:19:57Z
dc.date.available2020-10-22T12:19:57Z
dc.date.issued2002
dc.description.abstractAbstract Interleukin-12 (IL-12) is an important regulatory cytokine in infection and immunity. Administration of IL-12 may reduce complications of severe malaria in rodents. Polymorphisms in IL12B, the gene encoding the IL-12 p40 subunit, influence the secretion of IL-12 and susceptibility to Type 1 diabetes. We therefore investigated whether IL12B polymorphisms may affect the outcome of severe malaria. Homozygosity for a polymorphism in the IL12B promoter was associated with increased mortality in Tanzanian children having cerebral malaria but not in Kenyan children with severe malaria. Furthermore, homozygotes for the IL12B promotor polymorphism had decreased production of nitric oxide, which is in part regulated by IL-12 activity. These studies suggest that IL12B polymorphisms, via regulation of IL-12 production, may influence the outcome of malaria infection in at least one African population.en_US
dc.identifier.citationMorahan, G., Boutlis, C.S., Huang, D., Pain, A., Saunders, J.R., Hobbs, M.R., Granger, D.L., Weinberg, J.B., Peshu, N., Mwaikambo, E.D. and Marsh, K., 2002. A promoter polymorphism in the gene encoding interleukin-12 p40 (IL12B) is associated with mortality from cerebral malaria and with reduced nitric oxide production. Genes and immunity, 3(7), p.414.en_US
dc.identifier.otherdoi.org/10.1038/sj.gene.6363909
dc.identifier.urihttp://hdl.handle.net/123456789/698
dc.language.isoenen_US
dc.publisherGenes and immunityen_US
dc.subjectinterleukin-12en_US
dc.subjectTh1–Th2en_US
dc.subjectSevere malariaen_US
dc.titleA promoter polymorphism in the gene encoding interleukin-12 p40 (IL12B) is associated with mortality from cerebral malaria and with reduced nitric oxide productionen_US
dc.typeArticleen_US

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