Moshi, Mainen J.2023-08-112023-08-112007Moshi, M.J., Mbwambo, Z.H., Nondo, R.S., Masimba, P.J., Kapingu, M.C. and Magelewanya, E.S., 2007. Anticonvulsant activity of Diospyros fischeri root extracts. African Journal of Traditional, Complementary and Alternative Medicines, 4(2), pp.226-230.DOI: 10.4314/ajtcam.v4i2.31212http://hdl.handle.net/123456789/1121Diospyros fischeri Gurke (Ebenaceae) is used in traditional medicine for the treatment of epilepsy. Dichloromethane, ethylacetate, and ethanol extracts of the roots, at doses between 100 and 1600 mg/kg BW, inhibited convulsions induced by the γ‐aminobutyric acid type A (GABAA) receptor antagonist, pentylenetetrazole (PTZ), in a dose dependent manner. The extracts also exhibited low toxicity against brine shrimps giving LC50 values between 45 .4 and 95.4 μg/ml. These results provide evidence for the potential of D. fischeri extracts to treat absence seizures, especially given their seemingly innocuous nature. Keywords: Diospyros fischeri; Pentylenetetrazole; Anticonvulsant activity; Brine shrimp toxicityenDiospyros fischeriPentylenetetrazoleAnticonvulsant activityArticle