Moshi, Mainen J.2023-08-112023-08-112005-04Kapingu, M.C., Mbwambo, Z.H., Moshi, M.J. and Magadula, J.J., 2005. Brine shrimp lethality of a glutarimide alkaloid from Croton sylvaticus Hochst. East and Central African Journal of Pharmaceutical Sciences, 8(1), pp.3-5.10.4314/ecajps.v8i1.9716http://hdl.handle.net/123456789/1088Cytotoxic properties of pure compounds from the leaves of roto on sylvaticus (Euphorbiaceae) against brine shrimp (Artemia salina) larvae were investigated. A glutarimide alkaloid, julocrotine (1) showed'very high cytotoxic activity with a LCs0 (95 % CI) value of 0.074 (0.052-0.105) pglml when tested in vitro while lupeol (2) and penduliflaworisin (3) were inactive in brine shrimp lethality test. The structures of the isolated compounds were determined by modern spectroscopic methods.enCroton sylvaticusEuphorbiaceaeJulocrotineArticle