Mgone, Charles S.2020-03-172020-03-172003Boutlis, C.S., Fagan, P.K., Gowda, D.C., Lagog, M., Mgone, C.S., Bockarie, M.J. and Anstey, N.M., 2003. Immunoglobulin G (IgG) responses to Plasmodium falciparum glycosylphosphatidylinositols are short-lived and predominantly of the IgG3 subclass. The Journal of infectious diseases, 187(5), pp.862-865.doi.org/10.1086/367897http://hdl.handle.net/123456789/367The induction of neutralizing immunity to Plasmodium falciparum toxins by vaccination has been proposed as a preventive strategy to limit the severity of malaria. For this approach to be successful, generation of a sustained immune response would be necessary. This study shows that immunoglobulin G (IgG)–subclass responses elicited by the proposed P. falciparum toxin glycosylphosphatidylinositol (GPI) in Papua New Guinean subjects 5–60 years old predominantly involve IgG3, with a lesser contribution from IgG1 and an absence of IgG2 and IgG4. IgG3 levels declined sharply within 6 weeks of pharmacological clearance of parasitemia in all subjects, whereas a significant decrease in IgG1 levels was seen only in subjects ⩽19 years old. Because the natural antibody response to P. falciparum GPIs is skewed toward the short-lived IgG3 subclass, a vaccination strategy with GPI analogues would likely require augmentation by costimulatory molecules, to induce a more persistent anti-GPI responseenAntibody formationImmune responseDrug clearanceArticle